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- W2393822385 abstract "[Objective]To establish the PRINS-FISH in the detection of metaphase chromosomes in the peripheral blood lymphocytes,and to perform its feasibility analysis in prenatal diagnosis.[Methods]The 2 autosomes(chromosome 18 cetromeric α-satellite sequence and chromosome 21 single copy sequence) in the peripheral blood lymphocytes of normal people were dual-color labelled by using single-color PRINS and single-color FISH.[Results]Chromosome 18(green) and chromosome 21(orange) were simultaneously marked in the same metaphase nucleus,the rate of successful labeling reached 96.2% and 93.6%,respectively,and the rate of dual-color labeling reached 91.3%.[Conclusion]This technique combines respective advantages of PRINS and FISH in detection of chromosomes in peripheral blood lymphocytes,and increases the diversity of target of detection,so as to lay foundation for its clinic application in prenatal diagnosis." @default.
- W2393822385 created "2016-06-24" @default.
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- W2393822385 date "2008-01-01" @default.
- W2393822385 modified "2023-09-23" @default.
- W2393822385 title "APPLICATION OF PRINS-FISH IN ANALYSIS OF HUMAN METAPHASE CHROMOSOMES" @default.
- W2393822385 hasPublicationYear "2008" @default.
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