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- W2393823452 abstract "Objective To examine the effects of Ac-YVAD-CMK( caspase-1 inhibitor) on generation of activated IL-1β and early brain injury( EBI) after subarachnoid hemorrhage( SAH). Methods The endovascular perforation model of SAH was produced and 112 mice were assigned to sham,SAH vehicle,and SAH N-Ac-Tyr-Val-Ala-Asp-chloromethyl ketone( Ac-YVAD-CMK,6 and 10mg / kg) groups. Vehicle was administered intraperitoneally 1 hour post-SAH. EBI was assessed in terms of mortality within 24 hours,neurological scores,brain water content at 24 and 72 hours,Evans blue dye extravasation and Western blot for IL-1β at 24 hours after SAH. Results Both High-dose( 10mg / kg) and low-dose( 6mg / kg) treatment group attenuated the mature IL-1β induction,but only High-dose( 10mg / kg) treatment group significantly improved neurological scores,mortality,brain edema and damage of brain blood-brain barrier compared with the vehicle group. Conclusion IL-1β activation may play an important role in the pathogenesis of EBI after SAH. Ac-YVAD-CMK can significantly alleviate EBI after SAH." @default.
- W2393823452 created "2016-06-24" @default.
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- W2393823452 date "2013-01-01" @default.
- W2393823452 modified "2023-09-22" @default.
- W2393823452 title "Effect of Ac-YVAD-CMK on early brain injury after subarachnoid hemorrhage in mice" @default.
- W2393823452 hasPublicationYear "2013" @default.
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