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- W2393837267 abstract "Objective To observe the changes of n-methyl-d-aspartate(NMDA) receptor subunit NR1,NR2A,and NR2B protein levels in rat's auditory cortex after early auditory deprivation.Methods Little sprague dawley rats were divided into auditory deprivation group(n=18) and control group(n=18) randomly.Each group was divided into 3-week-old group,5-week-old group and 7-week-old group(n=6).Amikacin was administered subcutaneously at a dosage of 500 mg/(kg·d),from the seventh(p7) up to the 16th(p16) postnatal day.Control group were injected saline intraperitoneally(i.p) at the same dosage and for the same course.Rats in each group were anesthetized by 10% Chloral hydrate after models successfully made and the protein of auditory cortex was gathered,the protein expressions of NR1,NR2A and NR2B were tested by western blot methods respectively.Results Compared with control group,the protein levels of NR1 in auditory cortex of auditory deprivation group in all ages decreased significantly(P0.05),the protein levels of NR2A in auditory cortex in auditory deprivation group at p3w and p5w decreased significantly(P0.05),and the protein levels of NR2B in auditory cortex in auditory deprivation group at p3w decreased significantly(P0.05).Conclusion The expression level of NMDA receptor subunit protein level reduces in rat's auditory cortex by early auditory deprivation,which might participate in the mechanism of damaged cognition after early auditory deprivation." @default.
- W2393837267 created "2016-06-24" @default.
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- W2393837267 date "2012-01-01" @default.
- W2393837267 modified "2023-09-25" @default.
- W2393837267 title "Influence of Early Auditory Deprivation on Expression of N-Methyl-D-Aspartate Receptor Subunit Protein Levels in Auditory Cortex of Rat" @default.
- W2393837267 hasPublicationYear "2012" @default.
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