Matches in SemOpenAlex for { <https://semopenalex.org/work/W2393838146> ?p ?o ?g. }
Showing items 1 to 59 of
59
with 100 items per page.
- W2393838146 abstract "Objective To investigate the possible roles of hemodynamics, circulating hormones, cell cation transport and cyclic nucleotides in left ventricular hypertrophy (LVH) of essential hypertension (EH) in vivo. Methods Blood pressure, total peripheral resistance (TPR) and plasma norepinephrine (NE), endothelin (ET), angiotensin Ⅱ (AngⅡ), endogenous digitalis like substances (EDLS) and atrial natriuretic peptide (ANP) were determined, along with the measurements of lymphocytic membrane ion pumps, cations and cyclic nucleotides in 45 EH patients with LVH (12 concentric hypertrophy, 33 eccentric hypertrophy), 30 normal subjects and 45 EH patients without LVH (as double concurrent controls). Multiple stepwise regression analysis was computed using left ventricular mass index (LVMI) as dependent variable and 22 parameters as independent variables. Results (1) In EH patients with LVH, increases were seen in systolic blood pressure, mean arterial pressure (MAP) and NE, ET, AngⅡ, EDLS and ANP as well as lymphocytic Na +, Ca 2+ , cAMP and cAMP/cGMP ratio, while Na + K + ATPase and Ca 2+ ATPase activities, K + and Mg 2+ decreased. (2) Five hormones were related respectively to ion pumps, Na +, Ca 2+ and cyclic nucleotides. (3) LVMI were correlated with NE, ET, AngⅡ and EDLS, Ca 2+ ATPase, Na +, cAMP and cAMP/cGMP ratio. (4) The regression equation revealed that NE, ET, Ca 2+ ATPase, Mg 2+ and cAMP were the independent factors affecting LVH. (5) TPR and AngⅡ were higher, K + was lower in concentric LVH than those in eccentric LVH. Conclusion The changes of hemodynamics, circulating hormones, cell cation transport and cyclic nucleotides, or their interaction may be involved in the pathogenesis of LVH in EH. NE, ET. Ca 2+ ATPase, Mg 2+ and cAMP seem to play more important parts in LVH . TPR , whereas AngⅡ and K + may relate to cocentric LVH." @default.
- W2393838146 created "2016-06-24" @default.
- W2393838146 creator A5034550194 @default.
- W2393838146 date "2001-01-01" @default.
- W2393838146 modified "2023-09-25" @default.
- W2393838146 title "Effects of circulating hormones, cell cation transport and cyclic nucleotides on left ventricular hypertrophy in essential hypertension" @default.
- W2393838146 hasPublicationYear "2001" @default.
- W2393838146 type Work @default.
- W2393838146 sameAs 2393838146 @default.
- W2393838146 citedByCount "0" @default.
- W2393838146 crossrefType "journal-article" @default.
- W2393838146 hasAuthorship W2393838146A5034550194 @default.
- W2393838146 hasConcept C126322002 @default.
- W2393838146 hasConcept C134018914 @default.
- W2393838146 hasConcept C167414201 @default.
- W2393838146 hasConcept C185592680 @default.
- W2393838146 hasConcept C2776002628 @default.
- W2393838146 hasConcept C2777097880 @default.
- W2393838146 hasConcept C2778069365 @default.
- W2393838146 hasConcept C2908929049 @default.
- W2393838146 hasConcept C71924100 @default.
- W2393838146 hasConcept C84393581 @default.
- W2393838146 hasConceptScore W2393838146C126322002 @default.
- W2393838146 hasConceptScore W2393838146C134018914 @default.
- W2393838146 hasConceptScore W2393838146C167414201 @default.
- W2393838146 hasConceptScore W2393838146C185592680 @default.
- W2393838146 hasConceptScore W2393838146C2776002628 @default.
- W2393838146 hasConceptScore W2393838146C2777097880 @default.
- W2393838146 hasConceptScore W2393838146C2778069365 @default.
- W2393838146 hasConceptScore W2393838146C2908929049 @default.
- W2393838146 hasConceptScore W2393838146C71924100 @default.
- W2393838146 hasConceptScore W2393838146C84393581 @default.
- W2393838146 hasLocation W23938381461 @default.
- W2393838146 hasOpenAccess W2393838146 @default.
- W2393838146 hasPrimaryLocation W23938381461 @default.
- W2393838146 hasRelatedWork W1976001463 @default.
- W2393838146 hasRelatedWork W1977057586 @default.
- W2393838146 hasRelatedWork W1982967535 @default.
- W2393838146 hasRelatedWork W1985490718 @default.
- W2393838146 hasRelatedWork W1996979315 @default.
- W2393838146 hasRelatedWork W1999342069 @default.
- W2393838146 hasRelatedWork W2019496271 @default.
- W2393838146 hasRelatedWork W2061574479 @default.
- W2393838146 hasRelatedWork W2084848280 @default.
- W2393838146 hasRelatedWork W2090592889 @default.
- W2393838146 hasRelatedWork W2095069855 @default.
- W2393838146 hasRelatedWork W2121761723 @default.
- W2393838146 hasRelatedWork W2165168573 @default.
- W2393838146 hasRelatedWork W2349937091 @default.
- W2393838146 hasRelatedWork W2419554633 @default.
- W2393838146 hasRelatedWork W2420684420 @default.
- W2393838146 hasRelatedWork W2436156322 @default.
- W2393838146 hasRelatedWork W2597834463 @default.
- W2393838146 hasRelatedWork W3141113968 @default.
- W2393838146 hasRelatedWork W12536447 @default.
- W2393838146 isParatext "false" @default.
- W2393838146 isRetracted "false" @default.
- W2393838146 magId "2393838146" @default.
- W2393838146 workType "article" @default.