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- W2393846247 abstract "Objective[WT5”BZ] To investigate the dynamic changes in contributory factors of energy expenditure and metabolism of glucose, proteins and fatty acid in early postburn phase and in sepsis. [WT5”HZ]Methods[WT5”BZ] Using flame burn and intravenous injection of endotoxin in sheep, we established an animal model of burn and sepsis. Changes in hemodyamics and REE were monitored continuously and circulating levels of endotoxin, TNF-α, IL-6, IL-8, and certain metabolic hormones were assayed accordingly. Dynamic changes in serum contents of glucose and lactate as well as the plasma amino acid spectrum were analyzed. [WT5”HZ]Results[WT5”BZ] The level of REE elevated significantly despite sufficient resuscitation in early postburn periods[(201 4±6 3) J·h -1 ·m -2 vs (165 2±14 3) J·h -1 ·m -2 ] and further elevated (352 5±17 6)J·h -1 ·m -2 with the establishment of endotoxemia after thermal injury. Systemic LPS[(0 19±0 02)-(0 33±0 04)EU·ml -1 vs (0 14±0 02)EU·ml -1 ], TNF-α[(156±31)-(330±45)pg·ml -1 vs (66±15)pg·ml -1 ], IL-6[(298±106)-(448±91)pg·ml -1 vs (213±65)pg·ml -1 ] and IL-8[(247±53)-(389±121)pg·ml -1 vs (180±98)pg·ml -1 ] increased significantly and were chronologically proportional to the elevation of REE. Oxygen delivery[(176±28)ml·min -1 ·m -2 vs (375±45)ml·min -1 ·m -2 ] and tissue oxygen consumption [(97±12)ml·min -1 ·m -2 vs (120±20)min -1 ·m -2 )]decreased temporarily in early postburn period and gradually elevated with resuscitation and the onset of sepsis. Plasma contents of insulin[(16 4±6 2)-(26 2±5 3)MU·ml -1 vs 15 3±4 8MU·ml -1 ), glucagon(219 6±77 0-330 4±96 1 ng·L -1 vs (200 3±166 8)ng·L -1 and cortisol[(25 2±6 7)ng·ml -1 vs (17 8± 3 5) ng·ml -1 ] increased in postburn period as compared with those of normal controls. Plasma contents of lactate[(9 8±1 7)-(15 0±5 0) mmol·ml -1 vs. (8 8±3 3) mmol·ml -1 , glucose[(5 8±0 8)-(10 8±2 1) mmol·ml -1 vs (4 7±0 7) mmol·ml -1 )]and urinary output of 3-MT[(275±148)-(351±140) mmol/24 h vs (187±99) mmol/24 h] were significantly higher in postburn period and in sepsis as compared with those in normal controls. [WT5”HZ]Conclusion[WT5”BZ] There is a significant metabolicenhancement in early postburn period and in sepsis which was closely related to the posttraumatic systemic inflammatory responses, finely tuned by certain metabolic hormones and motivated by the enhancement of cellular metabolism of certain tissues. The animal model of burn and sepsis in sheep provides an ideal subject for the analysis of metabolic derangement in thermal injury and in sepsis. [WT5”HZ]" @default.
- W2393846247 created "2016-06-24" @default.
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- W2393846247 date "2001-01-01" @default.
- W2393846247 modified "2023-09-26" @default.
- W2393846247 title "Dynamic changes in metabolism in sheep after thermal injury and in sepsis" @default.
- W2393846247 hasPublicationYear "2001" @default.
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