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- W2393859513 abstract "Objective To observe the DNA damage in the human lung fibroblasts(HLF)induced by insoluble nickel compounds(Ni3S2 and Ni2O3)and soluble nickel compound(NiSO4),and to study the mechanism of carcinogenesis.Methods The DNA damage of HLF cells treated with different concentrations of Ni3S2,Ni2O3 and NiSO4 were detected with the method of single cell gel electrophoresis(SCGE).Results All of the three kinds of nickel compounds significantly caused DNA damage in HLF cells,the average tail moments of all nickel-treated groups were larger than those in the control group(P0.01).Conclusion Nickel compounds can induce DNA damage and the damage caused by insoluble compounds was much severely compared with soluble compounds.Maybe DNA damage is the possible mechanism of carcinogenesis induced by nickel compounds." @default.
- W2393859513 created "2016-06-24" @default.
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- W2393859513 date "2007-01-01" @default.
- W2393859513 modified "2023-09-23" @default.
- W2393859513 title "Nickel Compound-induced DNA Damage in Human Lung Fibroblasts" @default.
- W2393859513 hasPublicationYear "2007" @default.
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