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- W2393880218 abstract "Objective To access the capability of LC/MS based metabonomics in the evaluation of different course of diabetic nephropathy in KK-Ay mice.Methods Thirty male KK-Ay mice and C57BL/6J mice each were studied at the age of eight weeks.A 24-hour urine collection was made for the tests of protein urine every four weeks.Blood serum were collected for biochemical and LC/MS analysis.Three mice of each group were sacrificed at the age of 8,12,20 weeks.Renal tissue was observed to assess pathologic change.Results The serum glucose,lipids,urine protein were increased in KK-Ay mice after the age of 12 weeks(P0.01).There were significant mesangial matrix accumulation at the age of 12 weeks and GBM thickening at the age of 20 weeks.Principal component analysis(PCA) can clearly identify the difference between the serum samples of KK-Ay mice from the C57BL/6J mice.Changes of metabomomics were earlier than that in the pathology and biochemistry of serum.the footprint of the metabolites could indicate the course of diabetic nephropathy in KK-Ay mice.Conclusions LC/MS based metabonomics could distinguish the KK-Ay mice from the C57/BL6J accurately,and indicate the course of diabetic.It therefore may be a promising new technology in diagnosing the DN of T2DM earlier." @default.
- W2393880218 created "2016-06-24" @default.
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- W2393880218 date "2010-01-01" @default.
- W2393880218 modified "2023-09-26" @default.
- W2393880218 title "Metabomomic study of blood serum in early diagnosis of type 2 diabetic nephrology" @default.
- W2393880218 hasPublicationYear "2010" @default.
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