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- W2393892013 abstract "Objective: To research the changes of structure and function of type Ⅰalveolar cell in rabbits with diabetic ketoacidosis(DKA)and explore its injury and repair mechanisms.Methods: Twelve male New Zealand rabbits were randomly divided into experimental group(n=6) and control groups(n=6).Experimental group was injected streptozocin(150 mg·kg-1) and alloxan monohydroate(150 mg·kg-1) and control group was given the same dose normal sodium chloride.After 72 hours,artery blood gas,urine acetone body and blood electrolyte were detected.Then the animals were killed and the lung tissue were examined by light microscope and ultrastructure.PDGF of immunohistology and acid phosphates(ACPase) of cytohistochemical examination were detected coincidentally.Results: Plasma glucose concentration values were 17 mmol·L-1 and urine acetone body appeared in experimental group,the normalization was kept in control group.Inflammatory cells in pulmonary alveolar cavity and thickness of the alveolar wall were founed,pulmonary hemorrhage and other changes were shown in experimental group.Immunohistochemical observation showed that expression of platelet-derived growth factor(PDGF)was significantly high in alveolar cell and microvascular wall in experimental group.Thickening of the alveolar basement membrane and type Ⅰalveolar cell and capillary endothelium damages were observed by electron microscope in experimental group.The activity of alkaline phosphates was increased in type Ⅰ alveolar cells.No changes were found in control groups.Conclusion: DKA induce type Ⅰ alveolar cells lesion,enhancing the activity of acid phosphates and the number of lysosome.Lysosome damage play an important role in the course of lung injure.The rebuild is started up at the same time with injury in DKA,PDGF participate in the process of restoring in DKA lungs." @default.
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- W2393892013 date "2011-01-01" @default.
- W2393892013 modified "2023-09-23" @default.
- W2393892013 title "Study on damage and repair of type I alveolar cells in experimental diabetic ketoacidosis rabbit lung" @default.
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