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- W2393896289 abstract "Objective:To investigate the effects of glutamine on the expression of intercellular adhesion molecule-1(ICAM-1)in lungs of rats with endotoxin-induced acute lung injury(ALI).Methods:Fifty male SD rats were randomly assigned to receive normal saline in group C,5 mg/kg of lipopolysaccharide(LPS)in group L,0.75 g/kg glutamine and then 5 mg/kg of LPS 1 hour later in group G1,0.75 g/kg glutamine and 5 mg/kg of LPS simultaneously in group G2,and 5 mg/kg of LPS and then 0.75 g/kg of glutamine 1 hour later in group G3,respectively.The rats were killed 4 hours after the injection of LPS.Reverse transcription polymerase chain reaction and immunohistochemical method were used to detect ICAM-1 mRNA and protein expression.Morphological changes in lungs were observed under light microscope.Results:Compared with group L,ICAM-1 mRNA and protein expression significantly decreased and morphological changes in the lungs were less severe in groups G1 and G2(all P0.01).No significant difference was found between groups L and G3.Conclusion:Early administration of glutamine could protect against endotoxin-induced acute lung injury." @default.
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- W2393896289 date "2007-01-01" @default.
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- W2393896289 title "Effects of glutamine on intercellular adhesion molecule-1 in lungs of rats with endotoxin-induced acute lung injury" @default.
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