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- W2393899852 abstract "【Objective】To investigate the changes and important roles of glycoprofiling on cell surface from ascites of liver cancer in mice.【Method】 Ascites mice were induced by injecting H22 cells into mice abdomen.Thirty-six mice were randomly divided into normal group(6 mice) and ascites group(20 mice).After 10 days the ascetic fluid was collected to separate the tumor cells and liver cells were extracted from normal mice after digesting.All cells were labeled with Acridine Orange(AO) cell tracking dye and detected by lectin microarray to analyze the cell surface glycoprofiling.【Result】Sia,GluNAc,GalNAc,Man and Gal increased on cell surface from ascites,only polyLacNAc and Lac/LacNAc were expressed on normal liver cell surface.【Conclusion】 The glycosylation of cell surface is increased in occurrence of hepatocarcinogenesis.The increasing expression of Sia,GluNAc,GalNAc,Man and Gal may play key roles in liver carcinogenesis." @default.
- W2393899852 created "2016-06-24" @default.
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- W2393899852 date "2010-01-01" @default.
- W2393899852 modified "2023-09-23" @default.
- W2393899852 title "Glycoprofiling of ascites cell surface in mice" @default.
- W2393899852 hasPublicationYear "2010" @default.
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