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- W2393912208 abstract "PURPOSE: To investigate the therapeutic effect of targeting hTERT combined cisplatin against Tca8133 cell line.METHODS: Oral cancer cell Tca8113 was cultured and transfected with siRNA -hTERT.Then,reverse transcription polymerase chain reaction and Western blotting were performed to detect the changes of mRNA and protein of hTERT.Finally,MTT assay and flow cytometry were used to analyse the proliferation and apoptosis of targeting hTERT combined cisplatin against Tca8133 cell line.The data analysis was performed with ANVOA using SPSS13.0 software package.RESULTS: siRNA-hTERT1 could down-regulate the expression of hTERT mRNA and protein.Both cisplatin and siRNA-hTERT could induce apoptosis and inhibit proliferation in Tac8113 cell line.Moreover,a synergic effect against proliferation and survival combined siRNA -hTERT1 with cisplatin in Tca8113 cell line was noted.CONCLUSION: Downregulation of the expression of hTERT could enhance the chemosensitivity of Tca8113 to cisplatin." @default.
- W2393912208 created "2016-06-24" @default.
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- W2393912208 date "2010-01-01" @default.
- W2393912208 modified "2023-09-25" @default.
- W2393912208 title "Downregulation hTERT with siRNA enhance the chemosensitivity of Tca8133 cell line to cisplatin" @default.
- W2393912208 hasPublicationYear "2010" @default.
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