Matches in SemOpenAlex for { <https://semopenalex.org/work/W2393915376> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W2393915376 abstract "The Janus kinase/signal transducer and activator of transcription (JAK/STAT) are a major signal transduction pathway in controlling and regulating a number of cytokine-mediated responses, including interferon-γ, interleukin-1 (IL-1), IL-6, IL-10 and IL-4. The JAK/STAT pathway is particularly elegant because of its very rapid and simple cytoplasm-to-nucleus signaling. Recently, it has been found that JAK/STAT pathway might also be involved in the regulation of high mobility group box-1 protein (HMGB1), which plays an important role as a potential late mediator of sepsis. Inhibition of the activation of JAK/STAT pathway can down-regulate the gene expression of HMGB1 in vital organs, especially in the liver and lungs. In addition, treatment with JAK/STAT pathway inhibitors can effectively prevent the occurrence and development of multiple organ dysfunction syndrome following sepsis, and the probable underlying mechanism of which involves a reduction of direct or indirect harmful effect of HMGB1. Over the past few years, numerous investigations have contributed to our knowledge of the JAK/STAT pathway and its role in cytokine-mediated abnormality of immune function as well as inflammatory response during sepsis, and it might be helpful in further identifying a potential strategy of intervention for posttraumatic or postburn sepsis. This review summarizes the salient features of JAK/STAT pathway and focuses on the pathophysiological role of JAK/STAT in regulating proinflammatory cytokine activity and HMGB1 expression in vivo." @default.
- W2393915376 created "2016-06-24" @default.
- W2393915376 creator A5026733115 @default.
- W2393915376 date "2004-01-01" @default.
- W2393915376 modified "2023-09-26" @default.
- W2393915376 title "Janus kinase/signal transducer and activator of transcription pathway and sepsis after trauma" @default.
- W2393915376 hasPublicationYear "2004" @default.
- W2393915376 type Work @default.
- W2393915376 sameAs 2393915376 @default.
- W2393915376 citedByCount "0" @default.
- W2393915376 crossrefType "journal-article" @default.
- W2393915376 hasAuthorship W2393915376A5026733115 @default.
- W2393915376 hasConcept C112392421 @default.
- W2393915376 hasConcept C126042315 @default.
- W2393915376 hasConcept C145430368 @default.
- W2393915376 hasConcept C157333092 @default.
- W2393915376 hasConcept C164027704 @default.
- W2393915376 hasConcept C171958077 @default.
- W2393915376 hasConcept C191732599 @default.
- W2393915376 hasConcept C203014093 @default.
- W2393915376 hasConcept C2776914184 @default.
- W2393915376 hasConcept C2778277574 @default.
- W2393915376 hasConcept C2778384902 @default.
- W2393915376 hasConcept C2778690821 @default.
- W2393915376 hasConcept C2778923194 @default.
- W2393915376 hasConcept C2780545709 @default.
- W2393915376 hasConcept C42362537 @default.
- W2393915376 hasConcept C502942594 @default.
- W2393915376 hasConcept C62478195 @default.
- W2393915376 hasConcept C65439459 @default.
- W2393915376 hasConcept C71924100 @default.
- W2393915376 hasConcept C86803240 @default.
- W2393915376 hasConcept C95444343 @default.
- W2393915376 hasConceptScore W2393915376C112392421 @default.
- W2393915376 hasConceptScore W2393915376C126042315 @default.
- W2393915376 hasConceptScore W2393915376C145430368 @default.
- W2393915376 hasConceptScore W2393915376C157333092 @default.
- W2393915376 hasConceptScore W2393915376C164027704 @default.
- W2393915376 hasConceptScore W2393915376C171958077 @default.
- W2393915376 hasConceptScore W2393915376C191732599 @default.
- W2393915376 hasConceptScore W2393915376C203014093 @default.
- W2393915376 hasConceptScore W2393915376C2776914184 @default.
- W2393915376 hasConceptScore W2393915376C2778277574 @default.
- W2393915376 hasConceptScore W2393915376C2778384902 @default.
- W2393915376 hasConceptScore W2393915376C2778690821 @default.
- W2393915376 hasConceptScore W2393915376C2778923194 @default.
- W2393915376 hasConceptScore W2393915376C2780545709 @default.
- W2393915376 hasConceptScore W2393915376C42362537 @default.
- W2393915376 hasConceptScore W2393915376C502942594 @default.
- W2393915376 hasConceptScore W2393915376C62478195 @default.
- W2393915376 hasConceptScore W2393915376C65439459 @default.
- W2393915376 hasConceptScore W2393915376C71924100 @default.
- W2393915376 hasConceptScore W2393915376C86803240 @default.
- W2393915376 hasConceptScore W2393915376C95444343 @default.
- W2393915376 hasLocation W23939153761 @default.
- W2393915376 hasOpenAccess W2393915376 @default.
- W2393915376 hasPrimaryLocation W23939153761 @default.
- W2393915376 hasRelatedWork W1976115519 @default.
- W2393915376 hasRelatedWork W1986625462 @default.
- W2393915376 hasRelatedWork W1993907859 @default.
- W2393915376 hasRelatedWork W2032278706 @default.
- W2393915376 hasRelatedWork W2036233373 @default.
- W2393915376 hasRelatedWork W2037448423 @default.
- W2393915376 hasRelatedWork W2040736415 @default.
- W2393915376 hasRelatedWork W2046566019 @default.
- W2393915376 hasRelatedWork W2056894900 @default.
- W2393915376 hasRelatedWork W2085877951 @default.
- W2393915376 hasRelatedWork W2086840459 @default.
- W2393915376 hasRelatedWork W2185741796 @default.
- W2393915376 hasRelatedWork W2381048009 @default.
- W2393915376 hasRelatedWork W2896180430 @default.
- W2393915376 hasRelatedWork W2942513301 @default.
- W2393915376 hasRelatedWork W3029461162 @default.
- W2393915376 hasRelatedWork W3134728477 @default.
- W2393915376 hasRelatedWork W3158906763 @default.
- W2393915376 hasRelatedWork W3199548090 @default.
- W2393915376 hasRelatedWork W3208933594 @default.
- W2393915376 isParatext "false" @default.
- W2393915376 isRetracted "false" @default.
- W2393915376 magId "2393915376" @default.
- W2393915376 workType "article" @default.