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- W2393922912 abstract "Objective To explore the effect of serum drawn from cardiopulmonary bypass(CPB) on pulmonary surfacant-associated protein A(SP-A) of cultural rat alveolar type Ⅱ epithelial cell(AT-Ⅱ). Methods A modified primary cultural method was established for AT-Ⅱ, the AT-Ⅱ with serum drawn from CPB was co-cultured and the change of AT-Ⅱ morphology and SP-A expression observed. Pentoxifylline(PTX) was used as protect agent. Results After adding the CPB serum, the morphology of cultural AT-Ⅱ showed injurious change, the desquamate pencentage increased, SP-A expression decreased at transcription and translation levels. PTX can effectively prevent the injurious effect of serum in CPB on AT-Ⅱ. Conclusion Serum after CPB can directly injure the rat AT-Ⅱ in vitro, it can also inhibit the SP-A expression at transcription and translation levels, which probably is the important reason for the quantity and quality abnormality of pulmonary surfactant in clinical operation. PTX is a good drug to prevent AT-Ⅱ injury both in vivo and in vitro." @default.
- W2393922912 created "2016-06-24" @default.
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- W2393922912 date "2001-01-01" @default.
- W2393922912 modified "2023-09-24" @default.
- W2393922912 title "The Effect of Serum in Cardiopulmonary Bypass on Surfacant-associated Protein of Cultural Rat Alveolar Type II Epithelial Cell" @default.
- W2393922912 hasPublicationYear "2001" @default.
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