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- W2393925692 abstract "Objective To investigate the relation between the temporal changes of oxyhemoglobin (HbO2), deoxygemoglobin (HbDeoxy) and methemoglobin(HbMet) concentrations in cerebrospinal fluid and the degree of cerebral vasospasm by observing the relation between the concentrations of the 3 materials after SAH and the velocity of blood in the cerebral arteries detected by TCD. Methods 27 patients admited within 24h after SAH were selected, the CSF of 27 patients were collected by lumber puncture on the 1st, 3rd, 5th, 7th, 10th and 14th day after SAH, the levels of HbO2, HbDeoxy and HbMet were measured by means of spectrophotometry. Detected the velocity of blood flow in MCA by TCD. Results Concentration of HbO2 increased from the 3rd day and peaked on the 7th day in patients after SAH ( P0. 05) compared with the levels of the 1st, 3rd and 14th day. Concentration of HbDeoxy peaked on the 7th day ( P0. 05) compared with the levels of the 1st, 3rd, 5th and 14th day. HbMet levels increased only slightly and peaked on the 14th day, compared the other days there was no significant difference ( P0. 05) . MCA blood flow velocity measured by TCD increased from the 5th day and reached the peak on the 7th day. MCA blood flow velocity showed positive correlation with the level of HbO2 ( r = 0. 906). Conclusion This study showed that the concentration of HbO2 and HbDeoxy increased in CSF during the development of delayed cerebral vasospam. The results supported the hypothesis that HbO2 is involved in the pathogenesis of delayed cerebral vasospam after SAH and suggested that HbDeoxy is a possible vasospastic agent. The study also showed that there was positive correlation between the blood flow velocity and the concentration of HbO2 in CSF after SAH, and the value of TCD in the diagnose of cerebral artery vasospasm." @default.
- W2393925692 created "2016-06-24" @default.
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- W2393925692 date "2004-01-01" @default.
- W2393925692 modified "2023-09-25" @default.
- W2393925692 title "A study on the effect of oxyhemoglobin in cerebral vasospasm after spontaneous subarachnoid hemorrhage" @default.
- W2393925692 hasPublicationYear "2004" @default.
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