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- W2393934863 abstract "Objective To investigate the effect of adriamycin on heme oxygenase-1 in rat lung ischemia-reperfusion injury. Methods Thirty-two healthy male Wistar rats were divided randomly into 4 groups (eight rats in each group), namely the surgical controls (group C), Adriamycin group (group ADM), ischemia-reperfusion group (group IR) and ADM+IR group (group ADM-IR). The unilateral lung ischemia-reperfusion model was replicated. Rats from each group were sacrificed after a process of lung cross-clamping for 45 minutes followed by reperfusion for 2 hours, and were then harvested for the right lung for histological study. The dry /wet weight ratio of lung tissue (D/W), injured alveolus rate (IAR), the activity of HO-1, the expression of HO-1 protein were measured respectively in different groups. Results The value of D/W and IAR were much higher in IR group and ADM-IR group than those in C group and ADM group (P0.01). The values of these parameters were significantly lower in ADM-IR group than in the IR group (P0.01). There was no significant difference between ADM group and normal group (P0.05). The activity of HO-1 and expression of HO-1 protein were much higher in ADM group, IR group and ADM-IR group than those in C group (P0.01), and these indexes in ADM-IR group increased more significantly (P0.01). Conclusion Adriamycin appeared to improve the activity of HO-1, up-regulate the expression of HO-1 protein. Ameliorate of lung IRI in rats may result from activation of HO-1 in lung tissue. Low-dose Adriamycin did not seem to cause evidenced injury in rat lung tissue." @default.
- W2393934863 created "2016-06-24" @default.
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- W2393934863 date "2009-01-01" @default.
- W2393934863 modified "2023-09-23" @default.
- W2393934863 title "Effect of adriamycin on heme oxygenase-1 in rat lung ischemia-reperfusion injury" @default.
- W2393934863 hasPublicationYear "2009" @default.
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