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- W2393938314 abstract "Objective: To investigate the feasibility and effectivity of using poly(hydr-oxybutyrate-co-hydroxyvalerate)(PHBV) as scaffolds for cartilage tissue engineering.Methods: PHBV porous scaffolds were fabricated using compressing molding,thermal processing and salt particulate leaching methods.Chondrocytes isolated from the articular cartilage were seeded into porous PHBV scaffolds.After incubation for 4 weeks in vitro,the chondrocytes cultured for 28 days on the scaffolds were examined by scanning electron microscopy(SEM).Chondrocytes PHBV constructs were implanted into the joint cave of the rabbit.Control groups were established by articular implantation of PHBV alone.The specimens were excised at 4,8 and 12 weeks,examined grossly and analyzed by haematoxylin cosine,toluidine blue staining and type Ⅱ collagen immunohistochemistry.Wakitani score was counted to evaluate the repairing effect.Results: SEM showed that chondrocytes could aggregate and synthesize extracellular matrix on the PHBV scaffolds.Both specimens harvested from rabbits and those cultured in vitro exhibited new cartilage formation.After 4 weeks,obvious new cartilage-like tissues were found with smooth surface and well-integrated with the surrounding tissues.Highly positive results were observed on histological and histochemical examinations.Conclusion: PHBV can be used as scaffolds for cartilage tissue engineering.The combinant of chondrocytes and PHBV mixture gel may be an ideal injectable tissue engineering cartilage." @default.
- W2393938314 created "2016-06-24" @default.
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- W2393938314 date "2009-01-01" @default.
- W2393938314 modified "2023-09-22" @default.
- W2393938314 title "Repairing of articular cartilage defect by allograft chondrocytes embedded in poly hydr-oxybutyrate-co-hydroxyvalerate scaffolds" @default.
- W2393938314 hasPublicationYear "2009" @default.
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