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- W2393947417 abstract "Purpose To investigate the protective effects and its mechanisms of calcium channel blockade and oxygen free radical catalase on ESW?induced kidney damage. Methods 120 female uninephrectomized model rats were randomly divided into six groups.After injected Verapamil and/or SOD,their kidneys were given 1 000 shocks at 14 kV.Then the urinary level of NAG、MDA、ET,the variation of creatinine clearance (CCr)and the kidney histopathological changes were observed. Results The variation of urinary NAG、MDA level and the CCr in the therapeutic groups were significantly lower than that of the controlled,and the pathological changes were also much slighter.There was no significant difference of the chemical and pathological changes when the dose of SOD increased from 20 thousand Units to 40 thousand Units per kg body weight.The urinary titer of ET decreased when verapamil was used.Combinding SOD with verapamil induced better protective effects. Conclusions Calcium channel blockade could decrease not only the degree of lipids perioxyizition,but also the relieve of ET.It had protective effects on ESW?induced kidney damage,and the effects were much more significant when combinded with SOD." @default.
- W2393947417 created "2016-06-24" @default.
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- W2393947417 date "2001-01-01" @default.
- W2393947417 modified "2023-09-25" @default.
- W2393947417 title "Protective Effects and Its Mechanisms of Drugs on ESW-induced Kidney Damage" @default.
- W2393947417 hasPublicationYear "2001" @default.
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