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- W2393979968 abstract "Objective To investigate the expression of heme oxygenase(HO)in pulmonary arteries of rats with hypoxic pulmonary hypertension(HPH).Methods A total of 60 rats were employed and equally divided into 5 groups(n=12 in each group),i.e.control(group Ⅰ),HPH(group Ⅱ),hemin(group Ⅲ),tin protoporphyrin(SnPP)(group Ⅳ),and low concentration CO group(group Ⅴ).Of them,the rats from middle 3 groups were treated with hypoxia under normal pressure for 7 h in every day except Sunday,consecutively for 3 weeks.Hemin and tin protoporphyrin(SnPP)were given half an hour before hypoxia while low concentration CO at 2 h after hypoxia.HO-1 activity of pulmonary arteries tissues was tested with ultraviolet spectrophotometry.The expression of HO was detected with reverse transcriptionpolymerase chain reaction(RT-PCR),immunohistochemical staining and in situ hybridization.Results ① The bilirubin production increased significantly in group [(396.28±69.62)pmol·mg-1·h-1],group [(668.56±189.29)pmol·mg-1·h-1],group [(267.38±88.59)pmol·mg-1·h-1]and group [(589.32±132.35)pmol·mg-1·h-1],as compared with those in group [(125.62±31.52)pmol·mg-1·h-1].② The levels of HO-1 mRNA expression of pulmonary arteries in group Ⅱ,group Ⅲ,group Ⅳ and group Ⅴ were significantly higher than those in group Ⅰ.The most significant HO-1 mRNA expression was found in group Ⅴ(P0.01).The levels of HO-1 mRNA expression of pulmonary arteries in group Ⅲ and group Ⅴ were higher than those in group Ⅱ,but it was lower in group Ⅳ than that in group Ⅱ.③ The strong positive granules of HO-1 were observed in pulmonary arteries intima and media in group Ⅱ,group Ⅲ and group Ⅳ,while group Ⅲ and group Ⅳ involved more positive granules of HO-1 as compared with those in group Ⅱ.④ The staining was deepened in three layers of the pulmonary arteries in group Ⅱ,while the staining was deepened more in group Ⅲ and group Ⅳ.No significant change was found in staining of HO-2 in different groups.Conclusion CO can up-regulate the expression of HO-1,and this may play important roles in the genesis and development of pulmonary hypertension." @default.
- W2393979968 created "2016-06-24" @default.
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- W2393979968 date "2009-01-01" @default.
- W2393979968 modified "2023-09-23" @default.
- W2393979968 title "Expression of heme oxygenase in pulmonary arteries of rats with hypoxic pulmonary hypertension" @default.
- W2393979968 hasPublicationYear "2009" @default.
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