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- W2393984688 abstract "Objective To study the role of PTEN variation in the pathogenesis of hepatocellular carcinoma(HCC). Methods Semi-quantitive reverse transcriptase polymerase chain reaction(RT-PCR) was adopted to detect the expression of PTEN gene in 30 HCC and their adjacent tissues as well as 16 normal liver tissues served as controls. Results The expression level of PTEN gene in the HCC tissues was significantly lower than that in the adjacent and normal liver tissues(F=6.785;q=4.269,4.549;P0.05).In lowly-differentiated HCC tissue,the expression of PTEN was much lower than that in the highly-and moderately-differentiated HCC tissues(t=3.266,P0.01). Conclusion The inactivation of PTEN is closely associated with the pathogenesis of hepatocellular carcinoma,and the expression of PTEN is highly related with the malignancy of the cancer,which suggests that the alternation of PTEN can serve as a prognostic predictor for this disease." @default.
- W2393984688 created "2016-06-24" @default.
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- W2393984688 date "2007-01-01" @default.
- W2393984688 modified "2023-09-27" @default.
- W2393984688 title "EXPRESSION OF PTEN GENE IN PRIMARY LIVER CANCER" @default.
- W2393984688 hasPublicationYear "2007" @default.
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