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- W2393989969 abstract "Objective To isolate and identify the secondary metabolites of Aspergillus sp.SCSIOW3 from deep sea with anti-Aβpeptide aggregation activity.Methods Components with anti-Aβpeptide aggregation activity were purified from fermentation products of Aspergillus sp.SCSIOW3 by ThT model guided isolation.The structures of active compounds were identified by spectroscopic analysis(NMR and MS)as well as comparison with literatures.Results Two citrinin type compounds,phenol A acid(1)and Penicitrinone A(2),with anti-Aβpeptide aggregation activity were identified fromAspergillus sp.SCSIOW3.Compound 2 exhibited comparable activity with positive control,EGCG,at 100μM.Conclusion This is the first report for citrinin type compounds showing anti-Aβpeptide aggregation activity,which has strong potentials for further research." @default.
- W2393989969 created "2016-06-24" @default.
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- W2393989969 date "2014-01-01" @default.
- W2393989969 modified "2023-09-28" @default.
- W2393989969 title "Studies on secondary metabolites produced by Aspergillus sp.SCSIOW3 isolated from deep sea and their anti-Aβ peptide aggregation activity" @default.
- W2393989969 hasPublicationYear "2014" @default.
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