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- W2393994559 abstract "Objective To investigate the continous inhibitory effect of low dose nimustine(ACNU),cisplatin(CDDP) and carboplatin(CBP) on the growth of glioblastoma cell line U87 in vitro.Methods U87 cells are divided into 2 groups:One mode is 24 h incubation of U87 with different concentration of ACNU,CDDP and CBP.DMEM was discarded,and incubate for another 24 h or 48 h in fresh DMEM without drugs(A group).Another mode is U87 incubated with ACNU,CDDP and CBP respectively.The growth inhibition rate of U87 was detected respectively by MTT assay in 24 h,48 h and 72 h(B group).Results The inhibitory rate of ACNU on the growth of U87 by 2 incubation modes of 48 h and 72 h had no difference(P0.05).The inhibitory rate of CDDP and CBP on the growth of U87 by continous incubation group(B group) is much higher than the group with discard drugs after 24 h(A group) after 48 h and 72 h incubation.The difference of the 2 groups is prominent(P0.05).Conclusion The inhibitory rate on the growth of U87 in vitro is proportional to the concentration and time of low dose chemotherapy drugs." @default.
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- W2393994559 date "2009-01-01" @default.
- W2393994559 modified "2023-09-27" @default.
- W2393994559 title "Inhibitory effect of low-dose chemotherapy drugs on the growth of glioblastoma cell line U87" @default.
- W2393994559 hasPublicationYear "2009" @default.
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