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- W2393998084 abstract "AIM:To investigate the association of killer cell immunoglobulin-like receptor(KIR) genotype and cytomegalovirus(CMV)-BK virus(BKV) reactivation / infection in the first year after renal transplantation.METHODS:KIR genotypes were analyzed by PCR with sequence-specific primers(PCR-SSP) in 48 renal transplant recipients and KIR genotypes were grouped into AA if they contained only the canonical group A haplotype genes.The genotype containing additional KIR genes was referred to BX,as it contained at least 1 group B haplotype.Real-time quantitative PCR for CMVBKV DNA was performed to test the viral load.The association of KIR genotype and CMV-BKV infection and the effect of KIR genotype on renal function were analyzed.RESULTS:No obvious difference in the concentration of immunosuppressant and the occurrence of CMV infection / reactivation in the first year after renal transportation was observed between KIRAA and KIR-BX genotype groups.However,there was a significantly negative correlation between KIR-BX genotype and the cumulative incidence of BKV infection / reactivation.The average concentration of serum creatinine over 1 ~ 12 months after operation in KIR-AA genotype group was lower than that in KIR-BX genotype group.The levels of blood urea nitrogen and uric acid showed no obvious difference between the 2 groups.CONCLUSION:There is a significantly negative correlation between KIR-BX genotype and the cumulative incidence of BKV infection / reactivation,but not CMV infection / reactivation in the first year after renal transplantation." @default.
- W2393998084 created "2016-06-24" @default.
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- W2393998084 date "2014-01-01" @default.
- W2393998084 modified "2023-09-23" @default.
- W2393998084 title "Polymorphisms of KIR gene and CMV-BKV DNA quantification in renal transplant recipients" @default.
- W2393998084 hasPublicationYear "2014" @default.
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