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- W2393998692 abstract "Objective:To investigate the effects of fructose-1,6-diphosphate (FDP) pretreatment on the expression of macrophage inflammatory protein 2 (MIP-2) in rats with acute lung injury (ALI) induced by lipopolysaccharide (LPS),and to explore its possible protective mechanism. Methods: The rat models with acute lung injury were established via femoral vein injection of lipopolysaccharide (LPS,5mg/kg). Thirty male SD rats were randomly divided into 3 groups (n=10): control group,LPS group and LPS+FDP group. Rats in LPS+FDP group pretreated with FDP (250 mg/kg) intrapentoneally 1 hour before LPS injection. Artery blood gases were analyzed 6 hours after LPS or normal saline administration. Samples of lung tissue were sent for the lung wet-to-dry weight ratio determination. The expression of MIP-2mRNA was detected by the method of RT-PCR; and content of TNF-a and IL-lβ were detected by the method of ELISA. Results: Compared with those of control group,the expression of MIP-2mRNA in the cytoplasm and the levels of TNF-a,IL-lβ and D/W in the lung tissue were increased in LPS group and LPS+FDP group (P0.05); while they were decreased in LPS+FDP group compared with those of LPS group (P0.05). Conclusions: FDP may decrease the contents of TNF-a and IL-lβ and alleviate the inflammation of acute lung injury in rat by down-regulating the expression of MIP-2 induced by LPS." @default.
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- W2393998692 date "2010-01-01" @default.
- W2393998692 modified "2023-09-23" @default.
- W2393998692 title "Effects of Fructose-1,6-diphosphate on the Expression of Macrophage Inflammatory Protein-2 in Rats With Lung Injury Induced by Lipopolysaccharide" @default.
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