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- W2394003428 abstract "In this paper, a kind of pH-sensitive hydrogel, poly [NVP-AA-PEGDA] was synthesized from N-vinyl-2-pyrrolidone (NVP), polyethylene glycol diacrylate (PEGDA) and acrylic acid (AA) through free radical polymerization, in which azobisisobutyronitrile (AIBN) was used as the free radical initiator and N,N?methylene bis(acryl-amide) (BIS) as the crosslinking agent. 5-fuorouracil (5-FU), an anti-cancer drug was entrapped in the polymer carrier. The in-vitro release studies were carried out in SIF and SGF buffer solution at 37℃. The results showed that the final equilibrium release percent was small, and release period long, when the drug entrapped was released in buffer solution with low pH value. Moreover, with the decrease of PEGDA content in the sample, the corresponding release curve became flat, release period became long, and final equilibrium release percent decreased." @default.
- W2394003428 created "2016-06-24" @default.
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- W2394003428 date "2003-01-01" @default.
- W2394003428 modified "2023-09-23" @default.
- W2394003428 title "Synthesis of pH-sensitive Polymeric Hydrogel and Studies of Its Drug Release Property" @default.
- W2394003428 hasPublicationYear "2003" @default.
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