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- W2394008647 abstract "Objective To investigate the effects of fosinopril,an angiotensin converting enzyme inhibitor(ACEI) on the protein expression of tissue plasminogen activator(tPA) and type-1 plasminogen activator inhibitor(PAI-1) in progressively sclerotic or fibrotic renal tissue of 5/6 nephrectomized rats.Methods The 5/6 nephrectomized SD rats as experimental animal models were treated with ACEI for 12 weeks,and were then sacrificed and collected for blood samples and remnant renal tissues.We evaluated the renal pathological lesions by PAS staining and the protein expression of tPA and PAI-1 by immunohistochemistry.The weight,blood pressure,proteinuria,serum/urine biochemical parameters were measured,respectively.Results After 5/6 nephrectomy,the rats experienced progressive renal failure as noted by proteinuria,hypertension,hyperlipidemia,elevated levels of serum creatinine and BUN,as well as occurrence of glomerulosclerosis and tubulointerstitial fibrosis over time.Immunostaining suggested down-regulated tPA expression and up-regulated PAI-1 expression in remnant renal tissue in untreated group.With ACEI treatment,the renal failure,hypertension and proteinuria ameliorated significantly,and the expressions of tPA and PAI-1 were reversed simultaneously,as compared with untreated group(P0.01) .Conclusion Fosinopril appeared to interfere with fibrosis process in remnant kidney by modulating or improving the disorders of tPA/PAI-1 system." @default.
- W2394008647 created "2016-06-24" @default.
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- W2394008647 date "2007-01-01" @default.
- W2394008647 modified "2023-09-23" @default.
- W2394008647 title "Effects of fosinopril,an angiotensin converting enzyme inhibitor,on tPA/PAI-1 functions in young rats with chronic renal failure" @default.
- W2394008647 hasPublicationYear "2007" @default.
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