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- W2394019968 abstract "Objective IL-13 is well known to play important role in the pathophysiology of atopic dermatitis( AD). The purpose of this study is to investigate the IL-13 polymorphisms for its association with AD. Methods We conducted a case-control study in patients with AD( n = 234) and healthy individuals( n = 411) in Korean- Chinese( n = 294) and Han( n = 360) populations of Yanbian region. The genotypes of SNPs rs1800925 and rs140828306 were determined by the method of SnaPshot Multiplex in 294 Korean-Chinese( 84 patients with AD and 210 healthy individuals) and 360 Han-Chinese( 150 patients with AD and 201 healthy individu- als). Results Both allele and genotype frequency of rs1800925 conformed to the predication of Hardy- Weinberg equilibrium. The frequency of T allele was higher in ethnic Korean campared to Han-Chinese( P = 0. 047),and the frequency of TT genotype was higher in Korean-Chinese compared to Han-Chinese. howev- er,there were no significant difference( P = 0. 094) between two groups. For Korean and Han,both allele and genotype frequency of rs1800925 in patients with AD showed no significant difference between patiens with AD and healthy control group( P 0. 05). Through all the samples from this study showed CC genotype in rs140828306( C / T) Locus. Conclusion The polymorphism of rs1800925 is not associated with susceptibili- ty of AD in Chinese population of Yanbian area. The rs1800925 polymorphism showed a racial difference in Korean and Han Chinese population. There is only genotype( C / T) in rs140828306 in Korean-Chinese and Han-Chinese populations of Yanbian region." @default.
- W2394019968 created "2016-06-24" @default.
- W2394019968 creator A5042659744 @default.
- W2394019968 date "2013-01-01" @default.
- W2394019968 modified "2023-09-23" @default.
- W2394019968 title "Association between Single Nucleotide Polymorphisms of Interleukin-13 Gene and Atopic Dermatitis in Chinese Korean and Han Populations of Yanbian Region" @default.
- W2394019968 hasPublicationYear "2013" @default.
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