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- W2394019985 abstract "Objective To explore the effects of angiotensin Ⅳ on the expression of choline acetyltransferase (ChAT) and its mRNA in hippocampus and cognitive function of diabetic rats. Methods 38 SD male rats were divided into normal,diabetic model and angiotensin Ⅳ treatment groups randomly. Diabetes was induced by a single peritoneal injection of streptozotocin. 11 weeks later,learning and memory behaviors were investigated by a spatial version of Morris water maze test. The expression of ChAT of all rats was examined with immunohistochemical method and its mRNA expression was detected by RT-PCR. Results Compared with diabetic model group,the changes of ChAT and its mRNA in hippocampus significantly increased in angiotensin Ⅳ treatment group(P0.05). Meanwhile,learning and memory grade in angiotensin Ⅳ treatment group were better than those in diabetic model group(P0.05). Conclusions Angiotensin Ⅳ could improve cognitive ability in diabetic rats by increasing the expression of ChAT and its mRNA levels." @default.
- W2394019985 created "2016-06-24" @default.
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- W2394019985 date "2010-01-01" @default.
- W2394019985 modified "2023-09-23" @default.
- W2394019985 title "Effects of angiotensin IV on the expression of choline acetyltransferase and the cognitive function of diabetic rats" @default.
- W2394019985 hasPublicationYear "2010" @default.
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