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- W2394037899 abstract "To investigate the inhibitive effect of Artesunate(Art) on tumor growth in tumor-bearing mice.Fivety-six female NIH mice which was subcutaneous implanted with Heps hepatoma cells(1.2×105) were divided into 7 groups,each group had eight mice.Group 1,Art 15 mg/kg (low dose)was injected by intra peritoneal (ip);group 2,Art 30mg/kg (middle dose)ip;group 3,Art 60mg/kg(high dose)ip,group 4,Art 30mg/kg po;group 5,ferralia 6.5mg/kg po and Art 15mg/kg ip;group 6,cyclophosphamide 10mg/kg ip as positive control;group 7,normal salinc ip as blank control.Inhibitive rates of Art by ip at doses of low,middle and high were 16.2%?12.2% and 80.4% respectively.Art with high dose(60mg/kg) had signifcance inhibitive effects on tumor growth(P0.01). The spleen weight increased with increasing dosage of Art suggested that Artesunate could promote the levels of immunity in Heps hepatoma mice.Medium dose of Art administered po and ip had different result with inhibitive rate of 77% in former,and 12.2% in later.Combination ferralia and Art had synergenic the inhibitive effect in tumor-bearing mice.[Conclusion]Art has inhibitive effect to Heps hepatoma in mice in certain range of dosage.Different administerial way result in different effect Combination of Art and ferralia has synergenic inhabitive effect." @default.
- W2394037899 created "2016-06-24" @default.
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- W2394037899 date "2004-01-01" @default.
- W2394037899 modified "2023-09-26" @default.
- W2394037899 title "Inhibitive Effect of Artesunate on Heps Hepatona in Mice" @default.
- W2394037899 hasPublicationYear "2004" @default.
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