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- W2394041316 abstract "Objective To study the changes of tumor necrosis factor-α( TNF-α) in multiple organs and its relationship with the organ injury in liver cirrhosis rats with intestinal bacterial translocation( BT). Methods Rats were divided into 3 groups,normal control( NC) group,BT negative( BT-) group and BT positive( BT+) group. ELISA was used to measure the TNF-α levels in ileum,liver,kidney and brain. Pathological analysis was used to measure the organ injury by Hematoxylin-eosin staining. The relationship of TNF-α with the organ injury was studied by statistical analysis.Results TNF-α levels in livers,ileums,brains,peripheral blood specimens in the BT+group were significantly higher than those in BT-group( P 0. 05). Pathological injury of ileums,livers,and brains were positively related to the TNF-α level in corresponding tissues and blood( r 0,P 0. 05). Conclusion BT-induced TNF-α involves in the multiple organ injury after liver cirrhosis,therefore benefiting the prevention and treatment of BT related complications after liver cirrhosis." @default.
- W2394041316 created "2016-06-24" @default.
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- W2394041316 date "2015-01-01" @default.
- W2394041316 modified "2023-09-23" @default.
- W2394041316 title "Changes of TNF-α levels in multiple organs of liver cirrhosis rats with intestinal bacterial translocation" @default.
- W2394041316 hasPublicationYear "2015" @default.
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