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- W2394049527 abstract "Objective To assess the antitumor value of hydroxycamptothecine (HCPT) and hyperthermia with hydroxycamptothecine on c57BL mice with Lewis lung carcinoma.Methods Tumor Growth Delay(TGD) were analysed at different groups.Results ①the TGD obtained at 41℃,42℃,43℃.hyperthermia was respectily 1.07 days,1 40 days,2 52 days,only 43℃ hyperthermia group was significantly raised compared with the controls( P 0 002).②The TGD aquireded at 1 mg/kg,2 mg/kg,4 mg/kg of HCPT was respectily 1 87 days,4 00 days,4 57 days,and were all prolonged( P 0 05 P 0 01 P 0 001).③The TGD was 4 86 days,5 57 days,7 14 days of groups of combined treatment of HCPT (2 mg/kg) and 41℃,42℃,43℃ hyperthermia,and tumor growth was inhibited markedly undergoing combined treatment of HCPT (2 mg/kg) and 43℃ hyperthermia.Connlusions ①The larger of the HCPT dose,the higher of chemotherapy effect.②The effect of hyperthermia was increased when the temperature was raised.③Hyperthermia can enhanced the effect of HCPT and no temperature threshold was observed between the combined treatment of HCPT and hyperthermia." @default.
- W2394049527 created "2016-06-24" @default.
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- W2394049527 date "2001-01-01" @default.
- W2394049527 modified "2023-09-25" @default.
- W2394049527 title "The Effect of Hyperthemia with Hydroxycamptothecine on Mice with Lewis Lung Carcinoma" @default.
- W2394049527 hasPublicationYear "2001" @default.
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