Matches in SemOpenAlex for { <https://semopenalex.org/work/W2394059575> ?p ?o ?g. }
Showing items 1 to 63 of
63
with 100 items per page.
- W2394059575 abstract "Aim To explore the effect of chemical synthesized curcumin(Cur) preconditioning on the expression of aquaporin 4(AQP-4) and cerebral edema after focal cerebral ischemia-reperfusion damage in rats.Methods Local ischemia/reperfusion model of middle cerebral artery occlusion(MCAO) was made by inserting a nylon thread into internal carotid artery in rats.72 healthy SD rats weighing 290~310 g were randomly divided into 3 groups: sham operated group(S)(n=18),ischemia/reperfusion group(I)(n=18),Cur group(C1 and C2)(n=18) which were preconditioned with cur 50 or 100 mg·kg-1 intraperitoneally 30 min before focal cerebral ischemia-reperfusion.In I group,NS was given instead of Cur and in S group,the carotid arteries were exposed without performing MCAO.The rats in I group and C1,C2 group were killed 24 hours after cerebral ischemia/reperfusion.Neurological scores were studied,method of dry/wet weight was used to observe water content,and Evans Blue(EB) was collected to observe the changes of blood-brain barrier(BBB) permeability.Expression of AQP-4 and activation of c-Jun N-terminal kinase(JNK) in rat brain were determined by Western blot.Results Sham operated group presented no neurological changes.The water content and EB in C1 and C2 group were significantly lower than those of Ⅰ group(P0.05).Curcumin could also alleviate the expression of AQP-4 and the phosphorylation of JNK(P0.05).The neurological deficiency scores in C1 and C2 groups were obviously higher than those of I group(P0.05).Conclusions Chemical synthesized curcumin can alleviate the expression of AQP-4 and the phosphorylation of JNK,therefore protect the structure of BBB and alleviate the cerebral edema which can exert the neuroprotective effect after focal cerebral ischemia and reperfusion." @default.
- W2394059575 created "2016-06-24" @default.
- W2394059575 creator A5089135718 @default.
- W2394059575 date "2011-01-01" @default.
- W2394059575 modified "2023-09-26" @default.
- W2394059575 title "Effects of chemical synthesized curcumin preconditioning on the expression of AQP-4 and cerebral edema after focal cerebral ischemia/reperfusion damage in rats" @default.
- W2394059575 hasPublicationYear "2011" @default.
- W2394059575 type Work @default.
- W2394059575 sameAs 2394059575 @default.
- W2394059575 citedByCount "0" @default.
- W2394059575 crossrefType "journal-article" @default.
- W2394059575 hasAuthorship W2394059575A5089135718 @default.
- W2394059575 hasConcept C126322002 @default.
- W2394059575 hasConcept C2776268601 @default.
- W2394059575 hasConcept C2777649898 @default.
- W2394059575 hasConcept C2778250585 @default.
- W2394059575 hasConcept C2779311647 @default.
- W2394059575 hasConcept C2779493303 @default.
- W2394059575 hasConcept C2780114680 @default.
- W2394059575 hasConcept C2780886150 @default.
- W2394059575 hasConcept C42219234 @default.
- W2394059575 hasConcept C541997718 @default.
- W2394059575 hasConcept C71924100 @default.
- W2394059575 hasConcept C98274493 @default.
- W2394059575 hasConceptScore W2394059575C126322002 @default.
- W2394059575 hasConceptScore W2394059575C2776268601 @default.
- W2394059575 hasConceptScore W2394059575C2777649898 @default.
- W2394059575 hasConceptScore W2394059575C2778250585 @default.
- W2394059575 hasConceptScore W2394059575C2779311647 @default.
- W2394059575 hasConceptScore W2394059575C2779493303 @default.
- W2394059575 hasConceptScore W2394059575C2780114680 @default.
- W2394059575 hasConceptScore W2394059575C2780886150 @default.
- W2394059575 hasConceptScore W2394059575C42219234 @default.
- W2394059575 hasConceptScore W2394059575C541997718 @default.
- W2394059575 hasConceptScore W2394059575C71924100 @default.
- W2394059575 hasConceptScore W2394059575C98274493 @default.
- W2394059575 hasLocation W23940595751 @default.
- W2394059575 hasOpenAccess W2394059575 @default.
- W2394059575 hasPrimaryLocation W23940595751 @default.
- W2394059575 hasRelatedWork W2210114002 @default.
- W2394059575 hasRelatedWork W2348468780 @default.
- W2394059575 hasRelatedWork W2352966134 @default.
- W2394059575 hasRelatedWork W2353715168 @default.
- W2394059575 hasRelatedWork W2354850802 @default.
- W2394059575 hasRelatedWork W2355321487 @default.
- W2394059575 hasRelatedWork W2357244159 @default.
- W2394059575 hasRelatedWork W2361628642 @default.
- W2394059575 hasRelatedWork W2366503896 @default.
- W2394059575 hasRelatedWork W2367206444 @default.
- W2394059575 hasRelatedWork W2370241682 @default.
- W2394059575 hasRelatedWork W2374686142 @default.
- W2394059575 hasRelatedWork W2378058437 @default.
- W2394059575 hasRelatedWork W2381638603 @default.
- W2394059575 hasRelatedWork W2382044813 @default.
- W2394059575 hasRelatedWork W2385428095 @default.
- W2394059575 hasRelatedWork W3028653920 @default.
- W2394059575 hasRelatedWork W3032322013 @default.
- W2394059575 hasRelatedWork W3032754594 @default.
- W2394059575 hasRelatedWork W3032889238 @default.
- W2394059575 isParatext "false" @default.
- W2394059575 isRetracted "false" @default.
- W2394059575 magId "2394059575" @default.
- W2394059575 workType "article" @default.