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- W2394072994 abstract "Objective To explore whether vasculogenic mimicry(VM) exists in non-small cell lung cancer(NSCLC) or not and elucidate its relationship to the expressions of E-cad or MMP-2.Methods Expressions of E-cad,MMP-2 and VM were examined by immunohistochemistry and histochemistry containing from 160 cases of NSCLC and 20 cases of normal lung tissue.Results The positive rates of E-cad and MMP-2,and VM in normal lung tissue were 100%,25.0% and 0% respectively and in NSCLC were 45.6%,66.3% and 36.9%.There were significant differences between normal lung and NSCLC tissues(P0.01).The expressions of E-cad,MMP-2 and VM were significantly related with tumor differentiation,lymph node metastasis,clinical stage,postoperative survival time(all P0.01).There was a negative correlation between expressions of E-cad and MMP-2.There was a negative correlation between expressions of E-cad and VM.And there was a positive relationship between VM and the expression of MMP-2.VM and overexpression of MMP2 were related poor prognosis: the survival rates were significantly lower in positive patients than those of negative patients(both P0.01);while the survival rate of the E-cad-positive was higher than that of E-cad-negative patients(P0.01).PTNM stage,lymph node metastasis,positive expressions of E-cad and MMP-2 and VM were independent prognostic factors of NSCLC(P0.01).Conclusions VM and the expressions of E-cad and MMP-2 are related to differentiation,lymph node metastasis,clinical stage and prognosis of NSCLC.The combined detection of E-cad,MMP-2 and VM has an important role in predicting the progression and prognosis of NSCLC." @default.
- W2394072994 created "2016-06-24" @default.
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- W2394072994 date "2012-01-01" @default.
- W2394072994 modified "2023-09-25" @default.
- W2394072994 title "Expressions of E-cad and MMP-2 in non-small cell lung cancer and their relationship to vasculogenic mimicry" @default.
- W2394072994 hasPublicationYear "2012" @default.
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