Matches in SemOpenAlex for { <https://semopenalex.org/work/W2394073558> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W2394073558 abstract "Objective To utilize cholinergic antagonists to examine the mechanism of action of the hypothermia and delayed febrile response to the organophosphate pesticide chlorpyrifos and its relationship with change in the heat loss from the tail. Methods Core temperature was monitored by telemetry in female rats maintained at an ambient temperature of 25 ℃. Tail skin temperature was measured at 1 h intervals with digital thermometer. The peripheral cholinergic antagonist, methylscopolamine (1 mg/kg) and central cholinergic antagonist, scopolamine (1 mg/kg ) were administered during the period of chlorpyrifos (25 mg/kg) induced hypothermia and hyperthermia. Results ①Chlorpyrifos led to a rapid reduction in core temperature concomitant with a marked elevation in the heat loss from the tail. The hypothermia and vasodilatory effects of chlorpyrifos were blocked by administration of scopolamine,but not by methylscopolamine. ②The delayed fever response was augmented by scopolamine but blocked by methylscopolamine. Conclusion The results indicate that organophosphate pesticide chlorpyrifos -induced hypothermia and vasodilatory response are mediated primarily through a central cholinergic pathway. Fever response is mediated primarily through a peripheral cholinergic pathway. On the other hand, the data provides a possible explanation for the persistent fever in human exposed to organophosphate pesticides and treated with atropine. Methyl scopolamine may be a more effective therapy in the treatment of the fever." @default.
- W2394073558 created "2016-06-24" @default.
- W2394073558 creator A5091446112 @default.
- W2394073558 date "2007-01-01" @default.
- W2394073558 modified "2023-09-23" @default.
- W2394073558 title "Effect of cholinergic antagonists on organophosphate pesticide chlorpyrifos induced changes in body temperature in the rat and its relationship with change in the heat loss from the tail" @default.
- W2394073558 hasPublicationYear "2007" @default.
- W2394073558 type Work @default.
- W2394073558 sameAs 2394073558 @default.
- W2394073558 citedByCount "0" @default.
- W2394073558 crossrefType "journal-article" @default.
- W2394073558 hasAuthorship W2394073558A5091446112 @default.
- W2394073558 hasConcept C100564792 @default.
- W2394073558 hasConcept C126322002 @default.
- W2394073558 hasConcept C134018914 @default.
- W2394073558 hasConcept C161176658 @default.
- W2394073558 hasConcept C170493617 @default.
- W2394073558 hasConcept C22885893 @default.
- W2394073558 hasConcept C2775859210 @default.
- W2394073558 hasConcept C2776304672 @default.
- W2394073558 hasConcept C2776588719 @default.
- W2394073558 hasConcept C2776885963 @default.
- W2394073558 hasConcept C2777390192 @default.
- W2394073558 hasConcept C2779949491 @default.
- W2394073558 hasConcept C31896038 @default.
- W2394073558 hasConcept C42219234 @default.
- W2394073558 hasConcept C6557445 @default.
- W2394073558 hasConcept C71924100 @default.
- W2394073558 hasConcept C86803240 @default.
- W2394073558 hasConcept C98274493 @default.
- W2394073558 hasConceptScore W2394073558C100564792 @default.
- W2394073558 hasConceptScore W2394073558C126322002 @default.
- W2394073558 hasConceptScore W2394073558C134018914 @default.
- W2394073558 hasConceptScore W2394073558C161176658 @default.
- W2394073558 hasConceptScore W2394073558C170493617 @default.
- W2394073558 hasConceptScore W2394073558C22885893 @default.
- W2394073558 hasConceptScore W2394073558C2775859210 @default.
- W2394073558 hasConceptScore W2394073558C2776304672 @default.
- W2394073558 hasConceptScore W2394073558C2776588719 @default.
- W2394073558 hasConceptScore W2394073558C2776885963 @default.
- W2394073558 hasConceptScore W2394073558C2777390192 @default.
- W2394073558 hasConceptScore W2394073558C2779949491 @default.
- W2394073558 hasConceptScore W2394073558C31896038 @default.
- W2394073558 hasConceptScore W2394073558C42219234 @default.
- W2394073558 hasConceptScore W2394073558C6557445 @default.
- W2394073558 hasConceptScore W2394073558C71924100 @default.
- W2394073558 hasConceptScore W2394073558C86803240 @default.
- W2394073558 hasConceptScore W2394073558C98274493 @default.
- W2394073558 hasLocation W23940735581 @default.
- W2394073558 hasOpenAccess W2394073558 @default.
- W2394073558 hasPrimaryLocation W23940735581 @default.
- W2394073558 hasRelatedWork W1919606661 @default.
- W2394073558 hasRelatedWork W1963485348 @default.
- W2394073558 hasRelatedWork W1978943723 @default.
- W2394073558 hasRelatedWork W1982957526 @default.
- W2394073558 hasRelatedWork W2004143555 @default.
- W2394073558 hasRelatedWork W2014495874 @default.
- W2394073558 hasRelatedWork W2032847644 @default.
- W2394073558 hasRelatedWork W2038251601 @default.
- W2394073558 hasRelatedWork W2040690166 @default.
- W2394073558 hasRelatedWork W2051931574 @default.
- W2394073558 hasRelatedWork W2062230324 @default.
- W2394073558 hasRelatedWork W2074841457 @default.
- W2394073558 hasRelatedWork W2086156157 @default.
- W2394073558 hasRelatedWork W2161967863 @default.
- W2394073558 hasRelatedWork W2284292766 @default.
- W2394073558 hasRelatedWork W2370135009 @default.
- W2394073558 hasRelatedWork W2413638896 @default.
- W2394073558 hasRelatedWork W2417928692 @default.
- W2394073558 hasRelatedWork W886607375 @default.
- W2394073558 hasRelatedWork W2044393986 @default.
- W2394073558 isParatext "false" @default.
- W2394073558 isRetracted "false" @default.
- W2394073558 magId "2394073558" @default.
- W2394073558 workType "article" @default.