Matches in SemOpenAlex for { <https://semopenalex.org/work/W2394080351> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W2394080351 abstract "Objective To study the effect of tanshinone Ⅱ A on the myocardial nitric oxide(NO)content and protein kinase C(PKC)in rats with hypertrophy myocardium induced by abdominal aorta constriction.Methods SD rats were underwent abdominal aorta constriction to establish pressure loaded left ventricular hypertrophy(LVH)model.All rats were grouped as follows:sham operation(n=8),untreated LVH(n=8),low dose tanshinone [10 mg/(kg·d),n=8],high dose tanshinone [20 mg/(kg·d),n=8] and valsartan [10 mg/(kg·d),n=8].The thickness of posterior wall(PWT)and interseptal septum(IST)were determined by echocardiography.Myocardial fiber dimension(MFD)were measured histologically.The level of NO in myocardium were assessed with nitric acid deoxidization method and PKC protein expression with Western blot.Results Low and high dose tanshinone didn't decrease SBP(low dose:188±11,high dose:187±14 vs untreated control:186±13 mm Hg,P0.05).However,both doses of tanshinone and valsartan decreased PWT,IST,LVMI and MFD as compared with untreated control(P0.01).Both doses of tanshinone and valsartan increased myocardial NO(low dose:12.8±1.7,high dose:12.0±1.4 vs untreated control:5.8±1.1 μmol/g,all P0.01),and decreased PKC protein in myocardium(low dose:0.605±0.051,high dose:0.519±0.062,valsartan:0.827±0.086 vs untreated control:1.291±0.117,all P0.01).Conclusion TanshinoneⅡ A reverses LVH independently from blood pressure.The mechanism by which tanshinone decreased hypertrophied myocardium may be mediating via decreases in PKC protein and increases in NO level." @default.
- W2394080351 created "2016-06-24" @default.
- W2394080351 creator A5022007284 @default.
- W2394080351 date "2007-01-01" @default.
- W2394080351 modified "2023-09-24" @default.
- W2394080351 title "Effect of Tanshinone II A on the Myocardial Nitric Oxide and Protein kinase C in Hypertrophied Left Ventricle in Rats" @default.
- W2394080351 hasPublicationYear "2007" @default.
- W2394080351 type Work @default.
- W2394080351 sameAs 2394080351 @default.
- W2394080351 citedByCount "0" @default.
- W2394080351 crossrefType "journal-article" @default.
- W2394080351 hasAuthorship W2394080351A5022007284 @default.
- W2394080351 hasConcept C126322002 @default.
- W2394080351 hasConcept C134018914 @default.
- W2394080351 hasConcept C164705383 @default.
- W2394080351 hasConcept C167414201 @default.
- W2394080351 hasConcept C174940676 @default.
- W2394080351 hasConcept C184235292 @default.
- W2394080351 hasConcept C185592680 @default.
- W2394080351 hasConcept C195794163 @default.
- W2394080351 hasConcept C2776002628 @default.
- W2394080351 hasConcept C2777387769 @default.
- W2394080351 hasConcept C2778921608 @default.
- W2394080351 hasConcept C2779980429 @default.
- W2394080351 hasConcept C2780520971 @default.
- W2394080351 hasConcept C519581460 @default.
- W2394080351 hasConcept C55493867 @default.
- W2394080351 hasConcept C71924100 @default.
- W2394080351 hasConcept C84393581 @default.
- W2394080351 hasConceptScore W2394080351C126322002 @default.
- W2394080351 hasConceptScore W2394080351C134018914 @default.
- W2394080351 hasConceptScore W2394080351C164705383 @default.
- W2394080351 hasConceptScore W2394080351C167414201 @default.
- W2394080351 hasConceptScore W2394080351C174940676 @default.
- W2394080351 hasConceptScore W2394080351C184235292 @default.
- W2394080351 hasConceptScore W2394080351C185592680 @default.
- W2394080351 hasConceptScore W2394080351C195794163 @default.
- W2394080351 hasConceptScore W2394080351C2776002628 @default.
- W2394080351 hasConceptScore W2394080351C2777387769 @default.
- W2394080351 hasConceptScore W2394080351C2778921608 @default.
- W2394080351 hasConceptScore W2394080351C2779980429 @default.
- W2394080351 hasConceptScore W2394080351C2780520971 @default.
- W2394080351 hasConceptScore W2394080351C519581460 @default.
- W2394080351 hasConceptScore W2394080351C55493867 @default.
- W2394080351 hasConceptScore W2394080351C71924100 @default.
- W2394080351 hasConceptScore W2394080351C84393581 @default.
- W2394080351 hasLocation W23940803511 @default.
- W2394080351 hasOpenAccess W2394080351 @default.
- W2394080351 hasPrimaryLocation W23940803511 @default.
- W2394080351 hasRelatedWork W141599729 @default.
- W2394080351 hasRelatedWork W2226496616 @default.
- W2394080351 hasRelatedWork W2265165828 @default.
- W2394080351 hasRelatedWork W2347827735 @default.
- W2394080351 hasRelatedWork W2357233243 @default.
- W2394080351 hasRelatedWork W2375380366 @default.
- W2394080351 hasRelatedWork W2416645178 @default.
- W2394080351 hasRelatedWork W2425657015 @default.
- W2394080351 hasRelatedWork W2460906718 @default.
- W2394080351 hasRelatedWork W2503637735 @default.
- W2394080351 hasRelatedWork W2903928999 @default.
- W2394080351 hasRelatedWork W2980570219 @default.
- W2394080351 hasRelatedWork W2994748854 @default.
- W2394080351 hasRelatedWork W3029646414 @default.
- W2394080351 hasRelatedWork W3030178544 @default.
- W2394080351 hasRelatedWork W3031612918 @default.
- W2394080351 hasRelatedWork W3031929097 @default.
- W2394080351 hasRelatedWork W3032483420 @default.
- W2394080351 hasRelatedWork W3178182493 @default.
- W2394080351 hasRelatedWork W3186655357 @default.
- W2394080351 isParatext "false" @default.
- W2394080351 isRetracted "false" @default.
- W2394080351 magId "2394080351" @default.
- W2394080351 workType "article" @default.