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- W2394090774 abstract "Objective:To investigate the changes of TGF-β 1 promoter activity in mesangial cell stimulated with oxidized low density lipoprotein(Ox-LDL),and to illustrate the possible cis-elements involved. Methodology:A deletion analysis of TGF-β 1 promoter was applied in SD rat mesangial cells to identify the putative regulatory elements.These deletions were tested for responsiveness to Ox-LDL by fusing them with the luciferase gene,and by measuring the relative enzymatic activity of luciferase after transient transfection of these constructions into SD rat renal mesangial cells. Results:With the stimulation of Ox-LDL,luciferase activity began to rise at the 12th hour and reached the maximum at the 36th hour.Measurement of relative luciferase activity showed that there were two regions that responded to Ox-LDL stimulation in rat mesangial cell.Possibilities existed that enhancer elements locate in the first regions(-1550 to -845,a region containing an accurate activator protein 1 binding sites,AP-1) and inhibitor elements locate in the latter region (-629 to -422). Conclusion:The positive transcriptional regulation of rat TGF-β 1 gene induced by Ox-LDL is probably mediated at least by AP1 transcription." @default.
- W2394090774 created "2016-06-24" @default.
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- W2394090774 date "2002-01-01" @default.
- W2394090774 modified "2023-09-23" @default.
- W2394090774 title "The cic-element response to oxidized low density lipoprotein of TGF-β_1 promoter in mesangial cell" @default.
- W2394090774 hasPublicationYear "2002" @default.
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