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- W2394095357 abstract "Aim:To explore the effects of Y-type maze training on the learning and memory abilities and the expression of Synaptophysin in hippocampus CA1 region in rats with global cerebral ischemia.Methods:A total of 90 SD rats were randomly divided into three groups:sham operation group,control group, and trained group. Global cerebral ischemic rat model was established by modified Pulsinelli's 4-vessel occlusion method in control group and trained group.Seven days after global cerebral ischemia, the rats were trained by Y-type maze. At the respective time point (7 d,14 d, and 21 d),the cognitive ability was evaluated by Y-type maze.Hematoxylin-eosin staining was applied to observe neuronal pathomorphological changes and the number of normal neurons in hippocampus CA1 region. Immunhistochemical method and photo analysis were used to identify the expression of Synaptophysin in hippocampus CA1 region.Results: After training for 7 d,14 d,and 21 d,the difference of cognitive ability among sham operation group,trained group,and control group was significent(P0.05).The number of normal neuron in hippocampal CA1 of control group and trained group at three time points were significantly lower than those of sham operation group (P0.05), and the number of nurmal neuron of trained group at 21 d was higher than that of control group (P0.05). There were significant difference on expression of Synaptophysin at three time points when control group compared with sham operation group (P0.05). And at 14 d and 21 d, the expression was higher in trained group than those of control group (P0.05).Conclusion: The training of Y-type maze could improve the learning and memory abilites in rats with global cerebral ischemia.Its mechanism is probably concerned improving Synaptophysin expression in hippocampus CA1 region." @default.
- W2394095357 created "2016-06-24" @default.
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- W2394095357 date "2008-01-01" @default.
- W2394095357 modified "2023-09-24" @default.
- W2394095357 title "Effects of maze training on learning and memory abilities in rats with global cerebral ischemia" @default.
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