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- W2394134324 abstract "Objective To investigate the effects of human atrial natriuretic peptide(hANP)on the expression of nuclear factor-kappaB(NF-κB)p65and content of TNF-a and IL-lβin the lungs induced by ventilator(VILI).Methods A rat model of lung injury induced by ventilation with high peak inspiratory pressure.Thirty male SD rat weighing 200~ 250g were randomly divided into 3groups(n=10each):group TV(traditional tidal volume VT=8mL/kg),group HV(high tidal volume VT=40mL/kg)and group HV+ hANP(treated with hANP 0.1g/kg.min after 30min ventilation). The animals were sacrificed at 4hafter mechanical ventilation.The lungs were immediately removed for determination of expression of NF-κB p65(Western blot),TNF-a and IL-lβcontent(enzymelinked immuno-sorbentassy,ELISA)and wet to dry weight ratio(W/D).Results Compared with group TV,the expression of NF-κB p65in the cell nucleus the level of TNF-a and IL-lβand W/D in the lungs was significantly increased in group HV and group HV+hANP compared with group HV(P0.05).Conclusion hANP treatment can attenuate the changes in NF-κB p65expression in the lung induced by ventilation.hANP may alleviate the inflammation of acute lung injury in rat." @default.
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- W2394134324 date "2014-01-01" @default.
- W2394134324 modified "2023-09-23" @default.
- W2394134324 title "The expression of NF-κB p65 in acute lung injury induced by ventilator in rat and effects of human atrial natriuretic peptide" @default.
- W2394134324 hasPublicationYear "2014" @default.
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