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- W2394136712 abstract "Objective To evaluate the effect of different doses of alendronate(ALN) on quality of life in postmenopausal women with osteoporosis or osteopenia.Methods 100 postmenopausal women aged 65.06 ± 6.86 y with osteopenia or osteoporosis received randomly standard-dose ALN (70 mg weekly) or low-dose ALN (70 mg every two weeks) for 12 months.The quality of life was evaluated by SF-36,including eight sections of physical functioning(PF),role-physical(RP),bodily pain(BP),general health (GH),vitality(VT),social functioning (SF),role-emotiona l(RE),mental health (MH).Bone mineral density (BMD) was measured by dual-energy x-ray absorptiometry and serum carboxy-telopeptide of type I collagen(β-CTX) and total alkaline phosphatase (ALP) levels were assessed by chemiluminescence immunoassay and automatic analyser,respectively.Results 92 women completed the treatment.BMD was obviously increased and serum bone turnover markers levels were significantly decreased in the two dosage groups after the treatment (P0.05).No differences in percentage changes were found in BMD and ALP levels between the two dosage groups,except in percentage changes of CTX (P0.05).The scores of PF (P=0.006),RP (P=0.002),BP(P =0.033),VT(P=0.006) and RE (P=0.011) were increased significantly after the treatment of standard-dose ALN.The scores of PF (P=0.015),GH (P=0.000) and SF (P=0.041) were increased significantly after the treatment of low-dose ALN.Conclusion Treatment with ALN of 70 mg/w or 70 mg/2w could not only effectively reduce serum bone turnover markers levels,increase BMD at lumbar spine and proximal femur in postmenopausal women with osteopenia or osteoporosis,but also could improve the quality of life of the patients." @default.
- W2394136712 created "2016-06-24" @default.
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- W2394136712 date "2013-01-01" @default.
- W2394136712 modified "2023-09-27" @default.
- W2394136712 title "Effect of alendronate treatment on quality of life in postmenopausal women with osteoporosis" @default.
- W2394136712 hasPublicationYear "2013" @default.
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