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- W2394142743 abstract "Objective To explore the influence of the new type signal transducer and activator of transcription 3( STAT3) inhibitors kifocitanib( KIF) on apoptosis and cell cycle of multiple myeloma( MM) cell OPM2 and U266. Methods The trypan blue staining was used to detect the influence of KIF on survival and proliferation of OPM2,U266 cell; Annexin V / PI double staining and flow cytometry instrument were adopted to measure the effects of KIF on apoptosis rate and cell cycle of OPM2,U266 cell. Results KIF inhibited the growth of OPM2,U266 cells,and presented the dose dependent and time dependent inhibition. KIF made OPM2,U266 cells stagnate in G0 / G1 phase,and induced the cell apoptosis. Conclusion KIF inhibits MM cell proliferation,induces MM cell apoptosis,and has resistance to MM cell activity." @default.
- W2394142743 created "2016-06-24" @default.
- W2394142743 creator A5085309607 @default.
- W2394142743 date "2014-01-01" @default.
- W2394142743 modified "2023-09-22" @default.
- W2394142743 title "Effect of a novel STAT3 inhibitor,kifocitanib on multiple myeloma cell apoptosis and cell cycle" @default.
- W2394142743 hasPublicationYear "2014" @default.
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