Matches in SemOpenAlex for { <https://semopenalex.org/work/W2394142811> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W2394142811 abstract "Objective To determine whether Camptothecin(CPT) could augment Cytosine arabinoside(Ara-C) activity and could change the phase of apoptosis in the cell cycle during combination treatments. Methods CPT,Ara-C,alone or in combination were added to a flask of Molt-4 cells in log phase growth, giving a final concentration of CPT (0.25 uM), Ara-C(1.00 uM) or CPT (0.25uM)+Ara-C(1.00uM).Incubation experiments with Ara-C or CPT were performed on MOLT-4 cells that were treated for 4 h.To observe cellular apoptotic shapes with confocal laser scanning microscopy.Furthermore,three different flow cytometric methods,including Sub-G1, API Assay and CyclinE/DNA, were used to analyze the cell cycle specificity of apoptosis and expression of CyclinE. For further analysis, express of Bcl-2 were assayed by western blot. Results CPT could augment Ara-C activity and increase the amount of apoptotic cells 。A synergistic interaction in the two drugs was found.Most apoptotic cells were observed in S phase of the cell cycle.Expression of CyclinE had been elevated and expression of Bcl-2 had been decreased. Conclusion There is a synergistic interaction in the two drugs combinations in S phase of the cell cycle.The interactions still occur at the same checkpoint in the cell cycle.Both CyclinE and Bcl-2 play a critical role in response to chemotherapy agents and checkpoint status has been implicated in cell sensitivity to these drugs." @default.
- W2394142811 created "2016-06-24" @default.
- W2394142811 creator A5015531883 @default.
- W2394142811 date "2004-01-01" @default.
- W2394142811 modified "2023-09-23" @default.
- W2394142811 title "Effects of camptothecin and cytosine arabinoside on cell cycle specificity of apoptotic cells during combination treatments in MOLT-4 cell lines in vitro" @default.
- W2394142811 hasPublicationYear "2004" @default.
- W2394142811 type Work @default.
- W2394142811 sameAs 2394142811 @default.
- W2394142811 citedByCount "0" @default.
- W2394142811 crossrefType "journal-article" @default.
- W2394142811 hasAuthorship W2394142811A5015531883 @default.
- W2394142811 hasConcept C105696609 @default.
- W2394142811 hasConcept C1491633281 @default.
- W2394142811 hasConcept C153911025 @default.
- W2394142811 hasConcept C185592680 @default.
- W2394142811 hasConcept C190283241 @default.
- W2394142811 hasConcept C202751555 @default.
- W2394142811 hasConcept C2778041864 @default.
- W2394142811 hasConcept C2778729363 @default.
- W2394142811 hasConcept C2779682216 @default.
- W2394142811 hasConcept C2779707156 @default.
- W2394142811 hasConcept C29537977 @default.
- W2394142811 hasConcept C502942594 @default.
- W2394142811 hasConcept C54355233 @default.
- W2394142811 hasConcept C553184892 @default.
- W2394142811 hasConcept C55493867 @default.
- W2394142811 hasConcept C62112901 @default.
- W2394142811 hasConcept C81885089 @default.
- W2394142811 hasConcept C86803240 @default.
- W2394142811 hasConcept C95444343 @default.
- W2394142811 hasConceptScore W2394142811C105696609 @default.
- W2394142811 hasConceptScore W2394142811C1491633281 @default.
- W2394142811 hasConceptScore W2394142811C153911025 @default.
- W2394142811 hasConceptScore W2394142811C185592680 @default.
- W2394142811 hasConceptScore W2394142811C190283241 @default.
- W2394142811 hasConceptScore W2394142811C202751555 @default.
- W2394142811 hasConceptScore W2394142811C2778041864 @default.
- W2394142811 hasConceptScore W2394142811C2778729363 @default.
- W2394142811 hasConceptScore W2394142811C2779682216 @default.
- W2394142811 hasConceptScore W2394142811C2779707156 @default.
- W2394142811 hasConceptScore W2394142811C29537977 @default.
- W2394142811 hasConceptScore W2394142811C502942594 @default.
- W2394142811 hasConceptScore W2394142811C54355233 @default.
- W2394142811 hasConceptScore W2394142811C553184892 @default.
- W2394142811 hasConceptScore W2394142811C55493867 @default.
- W2394142811 hasConceptScore W2394142811C62112901 @default.
- W2394142811 hasConceptScore W2394142811C81885089 @default.
- W2394142811 hasConceptScore W2394142811C86803240 @default.
- W2394142811 hasConceptScore W2394142811C95444343 @default.
- W2394142811 hasLocation W23941428111 @default.
- W2394142811 hasOpenAccess W2394142811 @default.
- W2394142811 hasPrimaryLocation W23941428111 @default.
- W2394142811 hasRelatedWork W1965453447 @default.
- W2394142811 hasRelatedWork W2000846945 @default.
- W2394142811 hasRelatedWork W2025049464 @default.
- W2394142811 hasRelatedWork W2042545356 @default.
- W2394142811 hasRelatedWork W2081217031 @default.
- W2394142811 hasRelatedWork W2105811685 @default.
- W2394142811 hasRelatedWork W2352258959 @default.
- W2394142811 hasRelatedWork W2354390803 @default.
- W2394142811 hasRelatedWork W2360672542 @default.
- W2394142811 hasRelatedWork W2371533680 @default.
- W2394142811 hasRelatedWork W2386110082 @default.
- W2394142811 hasRelatedWork W2386670487 @default.
- W2394142811 hasRelatedWork W2416157877 @default.
- W2394142811 hasRelatedWork W2419661009 @default.
- W2394142811 hasRelatedWork W2428130967 @default.
- W2394142811 hasRelatedWork W2620638651 @default.
- W2394142811 hasRelatedWork W3007291473 @default.
- W2394142811 hasRelatedWork W3025689564 @default.
- W2394142811 hasRelatedWork W3143671473 @default.
- W2394142811 hasRelatedWork W339108734 @default.
- W2394142811 isParatext "false" @default.
- W2394142811 isRetracted "false" @default.
- W2394142811 magId "2394142811" @default.
- W2394142811 workType "article" @default.