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- W2394147529 abstract "Objectives: To investigate the gene expressions of smooth candida mycoderma bacteria in resistantance to triazoles antifungal drugs.Method: Thirty-four samples identified as smooth candida mycoderma bacteria through 26S rDNA D1 / D2 area,were administered with drug sensitivity test through French Merry biological medicine sensitive kit yeast ATBTM FUNGUS3.Real-time fluorescence quota polymerase chain reaction(PCR) was used to detect the expression of resistance genes CDR1,CDR2,SNQ2.Results: Of 34 strains of smooth candida mycoderma,two were sensitive strains,two were dose-dependent on ITR,and 30 were drug-resistant strains presenting cross resistance phenomenon.The resistance rates to FCA,ITR,VRC were 26.32%,86.84%,34.21% respectively.The expression rate of resistance genes CDR1,SNQ2 was significantly higher than that of the sensitive strains(P0.0005),but no difference was seen in CDR2 expression(P0.05).Conclusion: The MIC value of candida glabrata to triazoles was high.Its low drug sensitivity is related to the over-expression of resistance genes CDR1,SNQ2." @default.
- W2394147529 created "2016-06-24" @default.
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- W2394147529 date "2012-01-01" @default.
- W2394147529 modified "2023-09-26" @default.
- W2394147529 title "Expression of drug resistance genes CDR1,CDR2,SNQ2n in smooth candida mycoderma bacteria" @default.
- W2394147529 hasPublicationYear "2012" @default.
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