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- W2394165005 abstract "Objective To investigate the clinical value of using vascular endothelial growth factor(VEGF)mRNA in the peripheral blood as marker for isolated tumor cells(ITC)for patients with osteosarcoma underwent the salvagetherapy combined with neoadjuvant chemotherapy.MethodsTwenty-seven patients with osteosarcoma underwent the salvagetherapy combined with neoadjuvant chemotherapy were collected in our hospital as group A.Ten patients with metastatic carcinoma as group B,10 cases with benign osteochondroma as group C and 10 healthy volunteers as group D.Fluorescent quantitative-PCR)was used to detect the specificity of VEGF mRNA expression in osteosarcoma patients and its perioperative dynamic changes in group A.Results The positive rate of VEGF mRNA before chemical therapy was 74.1% in group A and 100% before operation in group B,which were significantly higher than 10.0% in group C before operation and 0% in group D.The changes of VEGF mRNA were fluctuated perioperatively in group A.Conclusion VEGF mRNA in peripheral blood as marker of ITC in osteosarcoma has high specificity and sensitivity.Dynamically monitoring the perioperative changes of VEGF mRNA is of importance for guiding chemical therapy in the patients with osteosarcoma." @default.
- W2394165005 created "2016-06-24" @default.
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- W2394165005 date "2010-01-01" @default.
- W2394165005 modified "2023-09-28" @default.
- W2394165005 title "Clinical application of VEGF mRNA as a marker for ITC in the salvagetherapy combined with neoadjuvant chemotherapy in patients with osteosarcoma" @default.
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