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- W2394166845 abstract "Objective:To study the anti-inflammatory effect of mizolastine on human skin inflammation induced by arachidonic acid(AA). Methods: 30 healthy volunteers were divided into two groups randomly. They were administrated either a single dose of mizolastine 10 mg or loratadine 10 .mg in a double-blind manner. Prick tests were performed by 8μl of prepared AA on inner side of forearms. Before antihistamines were given orally 1h and after 2h and 3 hr, the sizes of erythema and wheal were measured separately 30 min after pricking. Results: Both the sizes of flush areas and wheal areas at the AA concentration of 20%, before and after mizolastine administration were significantly different ( P 0.05, P 0.01). The sizes of wheal areas AA concentration of 40% and 4%, before and after mizolastine administration were significantly different ( P 0.05). There was no difference between the anti-inflammatory effects of mizolastine after 2h and 3h ( P 0.05). Loratadine showed no significant inhibition on the inflammatory action of 4%AA and 20%AA and 40% ( P 0.05). Conclusion: Mizolastine had a strong inhibitory effect on the AA-induced inflammation of human skin." @default.
- W2394166845 created "2016-06-24" @default.
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- W2394166845 date "2003-01-01" @default.
- W2394166845 modified "2023-09-23" @default.
- W2394166845 title "Anti-inflammatory effect of mizolastine on human skin inflammation induced by arachidonic acid" @default.
- W2394166845 hasPublicationYear "2003" @default.
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