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- W2394176859 abstract "Objective To observe the effect of intrathecal injection with yohimbin on the analgesia of isoflurane and investigate the relation between α2-adrenoceptor in the spinal cord and the analgesia of isoflurane.Methods The analgesic model was established by intraperitoneal injection of isoflurane in mice.Analgesia tests were investigated with warm water tail-flick test and acetic-induced writhing test.The effect of intrathecal with α2-adrenocerptor antagonist yohimbine(5 μg and 15 μg) on tail-flick latency(TFL) and the writhing times of the analgesic model was studied.Results Significant analgesia effect was observed following single isoflurane injection,i.p.(P0.01).Intrathecal injection of α2-adrenocerpto antagonist yohimbine(5 μg and 15 μg) alone had no effect on awakening mice from TFL and on writhing times(P0.05).Intrathecal injection with either dose of yohimbin reduced the TFL of the analgesic models(P0.01),though,no significant effect on the mouse writhing times was observed(P0.05).Conclusion Analgesia of isoflurane on the physical pains caused by thermal irritation is related to α2-AR in the spinal cord,while there may be no relation between α2-AR in the spinal cord and the analgesia of isoflurane on the pains resulting from chemical irritation." @default.
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- W2394176859 date "2008-01-01" @default.
- W2394176859 modified "2023-09-25" @default.
- W2394176859 title "The effect of intrathecal injection with yohimbin on the analgesia of isoflurane" @default.
- W2394176859 hasPublicationYear "2008" @default.
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