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- W2394181300 abstract "Objective To discuss the characteristics of rat myocardial damage induced by T-2 toxin in low protein and low selenium and observe the protection of supplementary selenium from this damage.Methods Wistar rat were fed with synthetic feed which was deficient in selenium and protein. After the rat was deficient in selenium(6w), 0.2 mg/kg body weight of T-2 toxin was given by gavage to rat every other day for 24 weeks. Using microscopy and electron-microscopy morphologically observed the lesions of myocardium, the T-2 toxin in myocardium was detected histochemically and the cardiocyte apoptosis was detected by TUNEL.Results The T-2 toxin expression was evident in the myocardium of rat given T-2 toxin by gavage, but there was no difference among different groups. The myocardial damage in the group deficient in protein and selenium was more serious than that in the group adequate in protein and selenium, and supplementary selenium could protect myocardium from damage.Conclusions T-2 toxins can remain in the myocardium.The deficiencies in protein and selenium can aggravate the damage induced by T-2 toxins and supplementary selenium has protective effect." @default.
- W2394181300 created "2016-06-24" @default.
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- W2394181300 date "2003-01-01" @default.
- W2394181300 modified "2023-09-25" @default.
- W2394181300 title "The experiment observation on rat myocardial damage induced by T-2 toxin in deficient of protein and selenium" @default.
- W2394181300 hasPublicationYear "2003" @default.
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