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- W2394200192 abstract "Objective To explore the effect of entecavir on the inflammatory regulatory protein Tyro3 in patients with chronic severe hepatitis B. Methods Patients or their guardians decided whether to use entecavir after being told about the benefits and hazards. 29 patients were diagnosed as chronic severe hepatitis B hospitalized in the Department of Infectious Diseases in the Second Affiliated Hospital of Shantou University Medical College from January 2012 to June 2013. 10 patients were in the control group,and 19 patients were in entecavir group,who received oral entecavir 0. 5 mg every day. The primary outcomes were the survival,the recovery of biochemistry and the level of HBV DNA at 4-week. The second outcomes were the concentrations of interleukin 6( IL-6),interferon α( IFN-α) and Tyro3 detected by ELISA and made the comparison between 2 groups. Results The 4 week survival rate of patients in entecavir group was significantly higher than that of the control group( P = 0. 003). The levels of total bilirubin,prothrombin time and HBV DNA were less than those in the control group( P0. 05). The level of IL-6 in entecavir group was less than that in the control group( P = 0. 007),while the level of Tyro3 was higher than that in the control group( P = 0. 011). Though the level of IFN-α was less than that in the control group,the difference was not significant( P = 0. 391). Conclusion Entecavir can remarkably improve the survival rate and liver function,and inhibit the replication of hepatitis virus B in patients with chronic severe hepatitis B,which may benefit from the up-regulating expression of Tyro3 which can down-regulate inflammatory factors,so the inflammatory response is relieved that delays the necrosis of liver cells." @default.
- W2394200192 created "2016-06-24" @default.
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- W2394200192 date "2014-01-01" @default.
- W2394200192 modified "2023-09-27" @default.
- W2394200192 title "Effect of Entecavir on Inflammatory Regulatory Protein Tyro3 in Patients with Chronic Severe Hepatitis B" @default.
- W2394200192 hasPublicationYear "2014" @default.
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