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- W2394202227 abstract "OBJECTIVE To develop a LC-MS/MS method for the simultaneous determination of pseudoephedrine,dextrorphan and diphenhydramine in human plasma. METHODS After phentolamine as the internal standard was added,the plasma samples were processed on solid phase extraction(SPE),then analyzed on a C18 column. The mobile phase was composed of methanol -0.5% formic acid (55∶45). Electrospray ionization source (ESI) was applied and operated in positive ion mode. Multiplereaction monitoring were used with mass transition of m/z 166.4→m/z 115.2,m/z 258.2→m/z 157.1,m/z 256.2→m/z 167.2 and m/z 282.2→m/z 212.2 for pseudoephedrine,dextrorphan,diphenhydramine and IS,respectively. RESULTS Standard curves were linear in the range of 1.0-200 μg·L-1 (r=0.999 3) for pseudoephedrine,0.05-10 μg·L-1 (r=0.999 1) for dextrorphan and 1.0～200 μg·L-1 (r=0.998 8) for diphenhydramine. The extraction recoveries were 67.4%-73.4% for pseudoephedrine,74.6%-75.7% for dextrorphan and 81.9%-83.9% for diphenhydramine. The RSDs of intra-day and inter-day assays were all less than 6.2%. The quantification limits of the method for pseudoephedrine diphenhydramine and dextrorphan were 1.0,1.0 and 0.05 μg·L-1,respectively. CONCLUSION The method was proved to be specific,sensitive and accurate,and suitable for clinical pharmacokinetic studies of pseudoephedrine,dextrorphan and diphenhydramine." @default.
- W2394202227 created "2016-06-24" @default.
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- W2394202227 date "2009-01-01" @default.
- W2394202227 modified "2023-09-23" @default.
- W2394202227 title "Simultaneous Determination of Pseudoephedrine,Dextrorphan and Diphenhydramine in Human Plasma by LC-MS/MS" @default.
- W2394202227 hasPublicationYear "2009" @default.
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