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- W2394236427 abstract "Objective:To evaluate the application of human papillomavirus(HPV) test in screening cervical epithelial lesions.Methods:580 cases were tested by thinprep cytology test(TCT),hybrid capture(HC-Ⅱ) and histopathology,then comparative analysis was performed by using the results of pathologic examination as diagnosis criteria.Results:①By pathological examination,207(35.69%),224(38.62%),96(16.55%),38(6.55%)and 15(2.58%)women were diagnosed as inflammation,CIN Ⅰ,CIN I,CIN Ⅲ and cervical cancer,respectively.② Among cases with abnormal cytology,52(25.12%)were inflammation,177(79.02%)CIN I,85(88.54%)CIN Ⅱ,36(94.74%)CIN Ⅲ,and 15(100%)cervical cancer,and there was a significant difference within groups(P0.05).③ Among the HPV DNA positive cases,66(31.88%)were inflammation,152(67.86%)CIN I,83(86.46%)CIN Ⅱ,35(92.11%)CIN III,and 15(100%)cervical cancer,and significant difference were found among the groups(P0.05 or 0.01),but not between CIN Ⅱ and CIN III(P0.05).Notably,the incidence of CIN and cervical cancer in HPV positive group were higher than HPV negative group(P0.01).④HPV detection rates in ≥30 years group was 65.53%,significantly higher than 34.47% in 30 years group(P0.01).⑤The combination of TCT and HPV-DNA test had better sensitivity(96.14%) and specificity(69.28%) than used alone.Conclusion:HPV infection is the main risk factor for CIN and cervical carcinoma,and plays an important role in the pathogenesis.The combination of HPV-DNA and TCT could improve detection rate of preinvasive and invasive cervical carcinoma." @default.
- W2394236427 created "2016-06-24" @default.
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- W2394236427 date "2011-01-01" @default.
- W2394236427 modified "2023-09-24" @default.
- W2394236427 title "Application of DNA Test of Human Papilloma Virusin in Cervical Lesion Screening" @default.
- W2394236427 hasPublicationYear "2011" @default.
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