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- W2394238249 abstract "Objective:To investigate whether three diallelic polymorphisms at-1082,-819 and-592 in the promoter region of the IL-10 gene were associated with ovarian carcinoma.Methods:The IL-10 gene-1082,-819 and-592 position polymorphisms were analyzed by sequence specific primers polymerase chain reaction(PCR-SSP) methods in 33 patients with ovary carcinoma and 90 healthy controls.Results:Compared with healthy subjects(HS),ovarian carcinoma patients had a great frequency of C/T genotype at IL-10 gene promoter-819 position(45.5% vs 21.0%,P0.05),the frequencies of-819 C/C and T/T genotype were not significantly different(6.1% vs 20.0% and 48.4% vs 59.0%,P0.05).ovarian carcinoma patients also had a great frequency of-592 C/A genotype at IL-10 compared with HS(45.5% vs 21.0%,P0.05),the frequencies of-529 C/C and A/A genotype were not significantly different(6.1% vs 20.0% and 48.4% vs 59.0%,P0.05).No significant difference was found in genotype at IL-10 gene promoter-1082 position.No significant difference was found in allele frequency at IL-10 gene-1082,-819 and-529 positions.Conclusion:The presence of-819C/T and C/A genotype may be related to development of ovarian carcinoma." @default.
- W2394238249 created "2016-06-24" @default.
- W2394238249 creator A5039859864 @default.
- W2394238249 date "2008-01-01" @default.
- W2394238249 modified "2023-09-26" @default.
- W2394238249 title "Association of interleukin-10 polymorphisms with susceptibility to ovarian cancer in Chinese Han population." @default.
- W2394238249 hasPublicationYear "2008" @default.
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