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- W2394260499 abstract "Objective:To explore the effect of vascular cell adhesion molecule-1(VCAM-1)in type 2 diabetes patients with coronary heart disease(CHD)and to study the protective role of rosiglitazone in those patients.Methods: There were three groups involved in this study.Patients with type 2 diabetes alone,n=40(Group A),patients with type 2 diabetes and CHD,n=40(Group B),and normal control subjects,n=40(Group C).Both patients' groups were treated with rosiglitazone 4 mg/d for 24 weeks.Serum VCAM-1 was detected by ELISA method before and after rosiglitazone treatment.Meanwhile,fasting plasma glucose(FPG),postprandial 2h plasma glucose(2hPG),homeostasis model assessment insulin resistance(HOMA-IR),hemoglobin Alc(HbA1c),TG,TC,LDL-C,HDL-C,BMI and blood pressure were measured and statistically analyzed.Results:The serum VCAM-1 in Group B was higher than both in Group A and in Group C.Serum VCAM-1 was positively correlated with blood pressure,FPG,2hPG,HOMA-IR,HbA1c,TG,TC and LDL-C.It was negatively correlated with HDL-C.After rosiglitazone treatment,the serum level of VCAM-1 decreased in all diabetes patients.Conclusion:After rosiglitazone treatment,serum level of VCAM-1 in patients with type 2 diabetes and CHD decreased to various degrees which indicating that rosiglitazone might have the preventive and treatment role in those patients." @default.
- W2394260499 created "2016-06-24" @default.
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- W2394260499 date "2008-01-01" @default.
- W2394260499 modified "2023-10-03" @default.
- W2394260499 title "Effect of Serum Vascular Cell Adhesion Molecule-1 on Type 2 Diabetes Patient With Coronary Heart Disease and the Protective Role of Rosiglitazone" @default.
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